Successful eradication of chronic myeloid leukemia in a child despite allogeneic graft rejection

Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs before pro...

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Bibliographic Details
Published in:Cancer reports 2022-10, Vol.5 (10), p.n/a
Main Authors: Vuorenoja, Susanna, Vettenranta, Kim, Lohi, Olli
Format: Article
Language:English
Subjects:
Abdomen
Blood
Bone marrow
Case Report
Case Reports
Chemotherapy
Children & youth
Cloning
CML
Conflicts of interest
eradication
graft rejection
HSCT
Immunology
Kinases
Leukemia
Neutrophils
Patients
Pediatrics
reconstitution
Remission (Medicine)
Transplants & implants
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Summary:Background Chronic myeloid leukemia (CML) is a rare disease in children and treated with tyrosine kinase inhibitors (TKI) and with allogeneic hematopoietic stem cell transplantation (HSCT) still in many cases. Case We describe an 8‐year‐old patient with CML treated with two different TKIs before proceeding to allogeneic HSCT. Despite successful engraftment, prompt rejection of the graft was followed by autologous reconstitution. TKI therapy was reintroduced post‐rejection in anticipation of relapse but shortly discontinued due to low white blood cell and neutrophil counts. The patient has remained disease‐free over 5 years after graft rejection and without further therapy. Conclusion This case suggests that even a short antileukemic effect by an allogeneic transplant may succeed in eradicating CML.
ISSN:2573-8348
2573-8348
DOI:10.1002/cnr2.1663