Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy

Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with signif...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-10, Vol.18 (11), p.2264
Main Authors: Villatoro, Antonio J, Fernández, Viviana, Claros, Silvia, Alcoholado, Cristina, Cifuentes, Manuel, Merayo-Lloves, Jesús, Andrades, José A, Becerra, José
Format: Article
Language:English
Subjects:
allogenic cell therapy
Cornea
Cytokines
dry eye
growth factor
Growth factors
Immunomodulation
Impact analysis
Inflammation
keratoconjunctivitis sicca
lacrimal gland
Lubrication
mesenchymal stem cell
Mesenchyme
Pathology
Quality of life
regenerative medicine
Review
Stem cells
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Summary:Dry eye syndrome is a complex and insidious pathology with a high level of prevalence among the human population and with a consequently high impact on quality of life and economic cost. Currently, its treatment is symptomatic, mainly based on the control of lubrication and inflammation, with significant limitations. Therefore, the latest research is focused on the development of new biological strategies, with the aim of regenerating affected tissues, or at least restricting the progression of the disease, reducing scar tissue, and maintaining corneal transparency. Therapies range from growth factors and cytokines to the use of different cell sources, in particular mesenchymal stem cells, due to their multipotentiality, trophic, and immunomodulatory properties. We will review the state of the art and the latest advances and results of these promising treatments in this pathology.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18112264