Biosynthesis of Medium- to Long-Chain α,ω-Diols from Free Fatty Acids Using CYP153A Monooxygenase, Carboxylic Acid Reductase, and E. coli Endogenous Aldehyde Reductases

α,ω-Diols are important monomers widely used for the production of polyesters and polyurethanes. Here, biosynthesis of α,ω-diols (C8-C16) from renewable free fatty acids using CYP153A monooxygenase, carboxylic acid reductase, and E. coli endogenous aldehyde reductases is reported. The highest yield...

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Bibliographic Details
Published in:Catalysts 2018-01, Vol.8 (1), p.4
Main Authors: Ahsan, Md, Sung, Sihyong, Jeon, Hyunwoo, Patil, Mahesh, Chung, Taeowan, Yun, Hyungdon
Format: Article
Language:English
Subjects:
Biosynthesis
carboxylic acid reductase
Catalysts
Chemical reactions
Chemical synthesis
CYP153A monooxygenase
Diols
E coli
Fatty acids
Lauric acid
Nicotinamide
Nicotinamide adenine dinucleotide
polyester
Polyester resins
Polyurethane resins
polyurethanes
Reductases
Regeneration
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Summary:α,ω-Diols are important monomers widely used for the production of polyesters and polyurethanes. Here, biosynthesis of α,ω-diols (C8-C16) from renewable free fatty acids using CYP153A monooxygenase, carboxylic acid reductase, and E. coli endogenous aldehyde reductases is reported. The highest yield of α,ω-diol was achieved for the production of 1,12-dodecanediol. In the nicotinamide adenine dinucleotide phosphate (NADPH) cofactor regeneration system, 5 g/L of 1,12-dodecanediol was synthesized in 24 h reaction from the commercial ω-hydroxy dodecanoic acid. Finally, 1.4 g/L 1,12-dodecanediol was produced in a consecutive approach from dodecanoic acids. The results of this study demonstrated the scope of the potential development of bioprocesses to substitute the petroleum-based products in the polymer industry.
ISSN:2073-4344
2073-4344
DOI:10.3390/catal8010004