Platelet Selectin Levels in Patients with Cerebral Venous Sinus Thrombosis: Preliminary Findings

• Published in: Journal of blood medicine 2023-01, Vol.14, p.359-365
• Main Authors: Zenobia, Eswi, Lailiyya, Nushrotul, Dian, Sofiati, Juli, Cep, Nugraha Hermawan, Asep, Amalia, Lisda
• Format: Article
• Language: English
• Subjects: Aprotinin; Blood clot; Care and treatment; cerebral venous sinus thrombosis; Clopidogrel; Development and progression; Fibrin; Health aspects; hypercoagulation; Indonesia; Medical research; Medicine, Experimental; Mortality; Original Research; p-selectin; platelet hyperaggregation; Thrombosis
• ISSN: 1179-2736; 1179-2736
• DOI: 10.2147/JBM.S405975

Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease with an estimated annual incidence of 3-4 cases per 1 million population with an 8% mortality rate caused by hypercoagulable conditions and hyper aggregation and also Platelet Selectin (P-Selectin) as one of coagulation biomarker for both of them. This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung. This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung. This is a descriptive observational study on patients ≥18 years old diagnosed with CVST at the Neurology outpatient polyclinic of RSUP Dr. Hasan Sadikin Bandung for March-May 2022. All samples that meet the inclusion criteria will be included as research subjects. There were 55 research subjects with a median age of 48 (range 22-69 years), the majority were women (80%), the most complaints were headaches (92.7%), the majority onset was chronic (96.4%) with a length of treatment ≥12 months (61.8%). P-selectin levels were found to increase in the group of subjects with subacute onset (mean 5.20 ± 2.977), infectious etiology (mean 5.26 ± 3.561), duration of treatment