The association between consanguineous marriage and offspring with congenital hearing loss

Consanguinity is a commonly recognized practice among marriages in the Middle East and may lead to an increase in the prevalence of inherited disorders. Autosomal recessive deafness is the most common form of inherited congenital hearing loss (CHL). Determine the association of consanguineous marria...

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Published in:Annals of Saudi medicine 2020-11, Vol.40 (6), p.456-461
Main Authors: Almazroua, Aljohara M, Alsughayer, Luluh, Ababtain, Rayanh, Al-Shawi, Yazeed, Hagr, Abdulrahman A
Format: Article
Language:English
Subjects:
Adult
Child
Child, Preschool
Consanguinity
Cross-Sectional Studies
Deafness - epidemiology
Deafness - genetics
Female
Hearing Loss, Sensorineural - congenital
Humans
Male
Marriage - ethnology
Middle East - epidemiology
Original
Pedigree
Risk Factors
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Summary:Consanguinity is a commonly recognized practice among marriages in the Middle East and may lead to an increase in the prevalence of inherited disorders. Autosomal recessive deafness is the most common form of inherited congenital hearing loss (CHL). Determine the association of consanguineous marriages with congenital sensorineural hearing loss (SNHL) and auditory neuropathy. Descriptive and analytical cross-sectional study. Ear specialist hospital. Children with severe-to-profound congenital SNHL, who had been referred to the specialist hospital for cochlear implant were analyzed. Patients were divided into subgroups based on degree of consanguinity. The relative risk of having more than one child with SNHL in offspring of a consanguineous marriage. 189 parents and children with CHL. The parents of 157 children (83.1%) were blood-related. Of those, 48 had more than one child with CHL (31.4%), while only two parents who were not blood-related had more than one child with CHL (6.25%; =.005). Among the 189 children, 131 (69.3%) parents were direct cousins. Only 39 (20.6%) and 43 (22.8%) children had family histories of CHL on the paternal and maternal sides, respectively. There was no statistically significant difference in the prevalence of auditory neuropathy between the offspring of consanguineous and non-consanguineous marriages ( =.648). The risk of having more than one child with SNHL in the offspring from a consanguineous marriage is 3.5 times higher than that of a non-consanguineous mating. The association of hearing loss degree with consanguinity was not studied. None.
ISSN:0256-4947
0975-4466
DOI:10.5144/0256-4947.2020.456