Bioactivity of NANOZR Induced by Alkali Treatment

In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO₂ polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing s...

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Bibliographic Details
Published in:International journal of molecular sciences 2017-04, Vol.18 (4), p.780-780
Main Authors: Nishizaki, Mariko, Komasa, Satoshi, Taguchi, Yoichiro, Nishizaki, Hiroshi, Okazaki, Joji
Format: Article
Language:English
Subjects:
alkali treatment
Alkaline phosphatase
Aluminum oxide
Aluminum Oxide - chemistry
Aluminum Oxide - pharmacology
Alveolar bone
Animals
bioactivity
Biological activity
Bone composition
Bone implants
Bone marrow
Bone Marrow Cells - cytology
Bone Marrow Cells - drug effects
Bovine serum albumin
Calcium
Cell adhesion
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Cells, Cultured
Dental Implants
Dental Materials - chemistry
Dental Materials - pharmacology
Dentistry
Deposition
Differentiation (biology)
Gene expression
Nanoparticles - chemistry
Osteocalcin
Osteogenesis
Osteogenesis - drug effects
Rats
Serum albumin
Surface Properties
Surgical implants
Transplants & implants
Wettability
Zirconia
zirconia/alumina nano-composite
Zirconium - chemistry
Zirconium - pharmacology
Zirconium dioxide
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Summary:In recent years, zirconia has been a recognized implant material in clinical dentistry. In the present study, we investigated the performance of an alkali-modified ceria-stabilized tetragonal ZrO₂ polycrystalline ceramic-based nanostructured zirconia/alumina composite (NANOZR) implant by assessing surface morphology and composition, wettability, bovine serum albumin adsorption rate, rat bone marrow (RBM) cell attachment, and capacity for inducing bone differentiation. NANOZR surfaces without and with alkali treatment served as the control and test groups, respectively. RBM cells were seeded in a microplate with the implant and cultured in osteogenic differentiation medium, and their differentiation was evaluated by measuring alkaline phosphatase (ALP) activity, osteocalcin (OCN) production, calcium deposition, and osteogenic gene expression. The alkali-treated NANOZR surface increased ALP activity, OCN production, calcium deposition, and osteogenesis-related gene expression in attached RBM cells. These data suggest that alkali treatment enhances the osteogenesis-inducing capacity of NANOZR implants and may therefore improve their biointegration into alveolar bone.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms18040780