Closed-loop direct control of seizure focus in a rodent model of temporal lobe epilepsy via localized electric fields applied sequentially

Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here...

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Bibliographic Details
Published in:Nature communications 2022-12, Vol.13 (1), p.7805-18, Article 7805
Main Authors: Kang, Wonok, Ju, Chanyang, Joo, Jaesoon, Lee, Jiho, Shon, Young-Min, Park, Sung-Min
Format: Article
Language:English
Subjects:
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Animals
Brain
Closed loops
Convulsions & seizures
Electric fields
Electric Stimulation
Electrical stimuli
Electrodes
Electroencephalography - methods
Engineering
Epilepsy
Epilepsy, Temporal Lobe - therapy
Hippocampus
Humanities and Social Sciences
Intervention
Investigations
multidisciplinary
Oscillations
Rats
Rodentia
Science
Science (multidisciplinary)
Seizures
Seizures - therapy
Stimulation
Temporal lobe
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Summary:Direct electrical stimulation of the seizure focus can achieve the early termination of epileptic oscillations. However, direct intervention of the hippocampus, the most prevalent seizure focus in temporal lobe epilepsy is thought to be not practicable due to its large size and elongated shape. Here, in a rat model, we report a sequential narrow-field stimulation method for terminating seizures, while focusing stimulus energy at the spatially extensive hippocampal structure. The effects and regional specificity of this method were demonstrated via electrophysiological and biological responses. Our proposed modality demonstrates spatiotemporal preciseness and selectiveness for modulating the pathological target region which may have potential for further investigation as a therapeutic approach. Direct stimulation of the focus of a seizure may have potential for the treatment of epilepsy. Here the authors demonstrate in a rat model a sequential narrow-field stimulation method for terminating seizures.
ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-35540-7