Functional effects of distinct innervation styles of pyramidal cells by fast spiking cortical interneurons

Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spin...

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Bibliographic Details
Published in:eLife 2015-07, Vol.4
Main Authors: Kubota, Yoshiyuki, Kondo, Satoru, Nomura, Masaki, Hatada, Sayuri, Yamaguchi, Noboru, Mohamed, Alsayed A, Karube, Fuyuki, Lübke, Joachim, Kawaguchi, Yasuo
Format: Article
Language:English
Subjects:
Animals
Cell Body - ultrastructure
Cell Communication
Dendrites - ultrastructure
Dendritic spines
Firing pattern
FS basket cell
inhibitory synapse
Innervation
Interneurons
Interneurons - physiology
IPSC
Laboratories
Microscopy, Electron
Neural Inhibition
Neuroscience
Physiology
pyramidal cell
Pyramidal cells
Pyramidal Cells - physiology
Rats, Wistar
Science
Software
spine
Synapses
Synapses - ultrastructure
synaptic conductance
Time-Lapse Imaging
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Summary:Inhibitory interneurons target precise membrane regions on pyramidal cells, but differences in their functional effects on somata, dendrites and spines remain unclear. We analyzed inhibitory synaptic events induced by cortical, fast-spiking (FS) basket cells which innervate dendritic shafts and spines as well as pyramidal cell somata. Serial electron micrograph (EMg) reconstructions showed that somatic synapses were larger than dendritic contacts. Simulations with precise anatomical and physiological data reveal functional differences between different innervation styles. FS cell soma-targeting synapses initiate a strong, global inhibition, those on shafts inhibit more restricted dendritic zones, while synapses on spines may mediate a strictly local veto. Thus, FS cell synapses of different sizes and sites provide functionally diverse forms of pyramidal cell inhibition.
ISSN:2050-084X
2050-084X
DOI:10.7554/elife.07919