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Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis
Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as well as beta-diversity (microbial diversity in different sam...
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| Published in: | International journal of molecular sciences 2021-04, Vol.22 (8), p.3998 |
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| container_issue | 8 |
| container_start_page | 3998 |
| container_title | International journal of molecular sciences |
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| creator | Olejniczak-Staruch, Irmina Ciążyńska, Magdalena Sobolewska-Sztychny, Dorota Narbutt, Joanna Skibińska, Małgorzata Lesiak, Aleksandra |
| description | Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as well as beta-diversity (microbial diversity in different samples) was noted in psoriasis skin. It has been proven that the representation of
,
spp., and
is decreased and
,
,
spp., and
spp. increased in the psoriasis skin in comparison to healthy skin. Alterations in the gut microbiome in psoriasis are similar to those observed in patients with inflammatory bowel disease. In those two diseases, the
,
spp.,
spp.,
and
were underrepresented, while the abundance of
sp.,
sp.,
sp.,
,
sp., and
sp. was increased. Several research studies provided evidence for the significant influence of psoriasis treatments on the skin and gut microbiome and a positive influence of orally administered probiotics on the course of this dermatosis. Further research is needed to determine the influence of the microbiome on the development of inflammatory skin diseases. The changes in microbiome under psoriasis treatment can serve as a potential biomarker of positive response to the administered therapy. |
| doi_str_mv | 10.3390/ijms22083998 |
| format | article |
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,
spp., and
is decreased and
,
,
spp., and
spp. increased in the psoriasis skin in comparison to healthy skin. Alterations in the gut microbiome in psoriasis are similar to those observed in patients with inflammatory bowel disease. In those two diseases, the
,
spp.,
spp.,
and
were underrepresented, while the abundance of
sp.,
sp.,
sp.,
,
sp., and
sp. was increased. Several research studies provided evidence for the significant influence of psoriasis treatments on the skin and gut microbiome and a positive influence of orally administered probiotics on the course of this dermatosis. Further research is needed to determine the influence of the microbiome on the development of inflammatory skin diseases. The changes in microbiome under psoriasis treatment can serve as a potential biomarker of positive response to the administered therapy.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22083998</identifier><identifier>PMID: 33924414</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abundance ; Arthritis ; Arthritis, Psoriatic - complications ; Arthritis, Psoriatic - microbiology ; Bacteria ; Cytokines ; Dendritic cells ; Deoxyribonucleic acid ; Digestive system ; DNA ; Dysbacteriosis ; Dysbiosis - complications ; Dysbiosis - microbiology ; Gastrointestinal Microbiome ; Humans ; Inflammation ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Intestinal microflora ; Lactobacilli ; Lymphocytes ; microbiome ; Microbiomes ; Microbiota ; Microorganisms ; Oral administration ; Pathogenesis ; Peptides ; Population ; Probiotics ; Probiotics - therapeutic use ; Proteins ; Psoriasis ; Psoriasis - complications ; Psoriasis - microbiology ; Psoriasis - therapy ; Psoriatic arthritis ; Review ; Salmonella ; Skin ; Skin - microbiology ; Skin diseases ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2021-04, Vol.22 (8), p.3998</ispartof><rights>2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c544t-ef1def2838ef7810c9a8b4386779c09faa64e565431275009e39ce8ece1a4b5c3</citedby><cites>FETCH-LOGICAL-c544t-ef1def2838ef7810c9a8b4386779c09faa64e565431275009e39ce8ece1a4b5c3</cites><orcidid>0000-0002-9709-3383</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2548646499/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2548646499?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33924414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olejniczak-Staruch, Irmina</creatorcontrib><creatorcontrib>Ciążyńska, Magdalena</creatorcontrib><creatorcontrib>Sobolewska-Sztychny, Dorota</creatorcontrib><creatorcontrib>Narbutt, Joanna</creatorcontrib><creatorcontrib>Skibińska, Małgorzata</creatorcontrib><creatorcontrib>Lesiak, Aleksandra</creatorcontrib><title>Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as well as beta-diversity (microbial diversity in different samples) was noted in psoriasis skin. It has been proven that the representation of
,
spp., and
is decreased and
,
,
spp., and
spp. increased in the psoriasis skin in comparison to healthy skin. Alterations in the gut microbiome in psoriasis are similar to those observed in patients with inflammatory bowel disease. In those two diseases, the
,
spp.,
spp.,
and
were underrepresented, while the abundance of
sp.,
sp.,
sp.,
,
sp., and
sp. was increased. Several research studies provided evidence for the significant influence of psoriasis treatments on the skin and gut microbiome and a positive influence of orally administered probiotics on the course of this dermatosis. Further research is needed to determine the influence of the microbiome on the development of inflammatory skin diseases. The changes in microbiome under psoriasis treatment can serve as a potential biomarker of positive response to the administered therapy.</description><subject>Abundance</subject><subject>Arthritis</subject><subject>Arthritis, Psoriatic - complications</subject><subject>Arthritis, Psoriatic - microbiology</subject><subject>Bacteria</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Deoxyribonucleic acid</subject><subject>Digestive system</subject><subject>DNA</subject><subject>Dysbacteriosis</subject><subject>Dysbiosis - complications</subject><subject>Dysbiosis - microbiology</subject><subject>Gastrointestinal Microbiome</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Intestinal microflora</subject><subject>Lactobacilli</subject><subject>Lymphocytes</subject><subject>microbiome</subject><subject>Microbiomes</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Oral administration</subject><subject>Pathogenesis</subject><subject>Peptides</subject><subject>Population</subject><subject>Probiotics</subject><subject>Probiotics - therapeutic use</subject><subject>Proteins</subject><subject>Psoriasis</subject><subject>Psoriasis - complications</subject><subject>Psoriasis - microbiology</subject><subject>Psoriasis - therapy</subject><subject>Psoriatic arthritis</subject><subject>Review</subject><subject>Salmonella</subject><subject>Skin</subject><subject>Skin - microbiology</subject><subject>Skin diseases</subject><subject>Tumor necrosis factor-TNF</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkU1P3DAQhq0KVCjtrecqEhcOLPg79gVptSoL0iIqtT1bjjNhvSQx2E4l_n1dlqKFk8czz7yamRehrwSfMabxud8MiVKsmNbqAzoknNIZxrLe24kP0KeUNhhTRoX-iA5KI-Wc8EN0O-8zRJt9GFMVuiqvofp578fKjm21nHJ1410MjQ8DVCX7I4XobfLpub79Ze-qeczr6LNPn9F-Z_sEX17eI_T78vuvxdVsdbu8XsxXMyc4zzPoSAsdVUxBVyuCnbaq4UzJutYO685ayUFIwRmhtcBYA9MOFDggljfCsSN0vdVtg92Yh-gHG59MsN48J0K8MzaWyXowmuiWMSGUEA13QmlZO9m1StRSAqnbonWx1XqYmgFaB2OOtn8j-rYy-rW5C3-MwlIrJovAyYtADI8TpGwGnxz0vR0hTMlQUfyRZQ1S0ON36CZMcSynKhRXkkuudaFOt1S5fUoRutdhCDb_XDe7rhf82-4Cr_B_m9lfV2KnjQ</recordid><startdate>20210413</startdate><enddate>20210413</enddate><creator>Olejniczak-Staruch, Irmina</creator><creator>Ciążyńska, Magdalena</creator><creator>Sobolewska-Sztychny, Dorota</creator><creator>Narbutt, Joanna</creator><creator>Skibińska, Małgorzata</creator><creator>Lesiak, Aleksandra</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-9709-3383</orcidid></search><sort><creationdate>20210413</creationdate><title>Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis</title><author>Olejniczak-Staruch, Irmina ; Ciążyńska, Magdalena ; Sobolewska-Sztychny, Dorota ; Narbutt, Joanna ; Skibińska, Małgorzata ; Lesiak, Aleksandra</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c544t-ef1def2838ef7810c9a8b4386779c09faa64e565431275009e39ce8ece1a4b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Abundance</topic><topic>Arthritis</topic><topic>Arthritis, Psoriatic - complications</topic><topic>Arthritis, Psoriatic - microbiology</topic><topic>Bacteria</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Deoxyribonucleic acid</topic><topic>Digestive system</topic><topic>DNA</topic><topic>Dysbacteriosis</topic><topic>Dysbiosis - complications</topic><topic>Dysbiosis - microbiology</topic><topic>Gastrointestinal Microbiome</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Intestinal microflora</topic><topic>Lactobacilli</topic><topic>Lymphocytes</topic><topic>microbiome</topic><topic>Microbiomes</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Oral administration</topic><topic>Pathogenesis</topic><topic>Peptides</topic><topic>Population</topic><topic>Probiotics</topic><topic>Probiotics - therapeutic use</topic><topic>Proteins</topic><topic>Psoriasis</topic><topic>Psoriasis - complications</topic><topic>Psoriasis - microbiology</topic><topic>Psoriasis - therapy</topic><topic>Psoriatic arthritis</topic><topic>Review</topic><topic>Salmonella</topic><topic>Skin</topic><topic>Skin - microbiology</topic><topic>Skin diseases</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olejniczak-Staruch, Irmina</creatorcontrib><creatorcontrib>Ciążyńska, Magdalena</creatorcontrib><creatorcontrib>Sobolewska-Sztychny, Dorota</creatorcontrib><creatorcontrib>Narbutt, Joanna</creatorcontrib><creatorcontrib>Skibińska, Małgorzata</creatorcontrib><creatorcontrib>Lesiak, Aleksandra</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olejniczak-Staruch, Irmina</au><au>Ciążyńska, Magdalena</au><au>Sobolewska-Sztychny, Dorota</au><au>Narbutt, Joanna</au><au>Skibińska, Małgorzata</au><au>Lesiak, Aleksandra</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-04-13</date><risdate>2021</risdate><volume>22</volume><issue>8</issue><spage>3998</spage><pages>3998-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Numerous scientific studies in recent years have shown significant skin and gut dysbiosis among patients with psoriasis. A significant decrease in microbiome alpha-diversity (abundance of different bacterial taxa measured in one sample) as well as beta-diversity (microbial diversity in different samples) was noted in psoriasis skin. It has been proven that the representation of
,
spp., and
is decreased and
,
,
spp., and
spp. increased in the psoriasis skin in comparison to healthy skin. Alterations in the gut microbiome in psoriasis are similar to those observed in patients with inflammatory bowel disease. In those two diseases, the
,
spp.,
spp.,
and
were underrepresented, while the abundance of
sp.,
sp.,
sp.,
,
sp., and
sp. was increased. Several research studies provided evidence for the significant influence of psoriasis treatments on the skin and gut microbiome and a positive influence of orally administered probiotics on the course of this dermatosis. Further research is needed to determine the influence of the microbiome on the development of inflammatory skin diseases. The changes in microbiome under psoriasis treatment can serve as a potential biomarker of positive response to the administered therapy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33924414</pmid><doi>10.3390/ijms22083998</doi><orcidid>https://orcid.org/0000-0002-9709-3383</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Abundance Arthritis Arthritis, Psoriatic - complications Arthritis, Psoriatic - microbiology Bacteria Cytokines Dendritic cells Deoxyribonucleic acid Digestive system DNA Dysbacteriosis Dysbiosis - complications Dysbiosis - microbiology Gastrointestinal Microbiome Humans Inflammation Inflammatory bowel disease Inflammatory bowel diseases Intestinal microflora Lactobacilli Lymphocytes microbiome Microbiomes Microbiota Microorganisms Oral administration Pathogenesis Peptides Population Probiotics Probiotics - therapeutic use Proteins Psoriasis Psoriasis - complications Psoriasis - microbiology Psoriasis - therapy Psoriatic arthritis Review Salmonella Skin Skin - microbiology Skin diseases Tumor necrosis factor-TNF |
| title | Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis |
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