Evaluation of serum platelet-derived growth factor receptor-ß and brain-derived neurotrophic factor levels in microvascular angina

Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA. Platelet-derived growth factor receptor β (PDGFR-β) and brain-derived neurotrophic factor (BDNF) are 2 biomarkers assoc...

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Bibliographic Details
Published in:Anatolian journal of cardiology 2020-12, Vol.24 (6), p.397-404
Main Authors: Aslan, Gamze, Polat, Veli, Bozcali, Evin, Şahin, Mustafa Hakan, Çetin, Nurcan, Ural, Dilek
Format: Article
Language:English
Subjects:
brain-derived neurotrophic factor
microvascular angina
Original Investigation
pericytes
platelet-derived growth factor receptor beta
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Summary:Microvascular angina (MVA) is a coronary microcirculation disease. Research on microcirculatory dysfunction has revealed several biomarkers involved in the etiopathogenesis of MVA. Platelet-derived growth factor receptor β (PDGFR-β) and brain-derived neurotrophic factor (BDNF) are 2 biomarkers associated with microcirculation, particularly pericytes function. The aim of this study was to investigate the role of PDGFR-β and BDNF in MVA. Ninety-one patients (median age, 56 y; age range, 40-79 y; 36 men) with MVA and 61 control group subjects (median age, 52 y; age range, 38-76 y; 29 men) were included in the study. Serum concentrations of PDGFR-β and BDNF were measured with commercially available enzyme-linked immunosorbent assay kits. PDGFR-β [2.82 ng/ml; interquartile range (IQR), 0.57-7.79 ng/ml vs. 2.27 ng/ml; IQR, 0.41-7.16 ng/ml; p
ISSN:2149-2263
2149-2271
2149-2263
DOI:10.14744/AnatolJCardiol.2020.44388