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Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta
Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor...
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| Published in: | eLife 2017-03, Vol.6 |
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| creator | Zamir, Lyad Singh, Reena Nathan, Elisha Patrick, Ralph Yifa, Oren Yahalom-Ronen, Yfat Arraf, Alaa A Schultheiss, Thomas M Suo, Shengbao Han, Jing-Dong Jackie Peng, Guangdun Jing, Naihe Wang, Yuliang Palpant, Nathan Tam, Patrick Pl Harvey, Richard P Tzahor, Eldad |
| description | Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor populations. We show that expression of the cardiac transcription factor
marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. Extra-cardiac
lineage progenitors migrate into the embryo and contribute to clusters of CD41
/CD45
and RUNX1
cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. We also demonstrated that ectopic expression of
in chick embryos activates the hemoangiogenic gene expression program. Taken together, we identified a hemogenic angioblast cell lineage characterized by transient
expression that contributes to hemogenic endothelium and endocardium, suggesting a novel role for
in hemoangiogenic lineage specification and diversification. |
| doi_str_mv | 10.7554/eLife.20994 |
| format | article |
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marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. Extra-cardiac
lineage progenitors migrate into the embryo and contribute to clusters of CD41
/CD45
and RUNX1
cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. We also demonstrated that ectopic expression of
in chick embryos activates the hemoangiogenic gene expression program. Taken together, we identified a hemogenic angioblast cell lineage characterized by transient
expression that contributes to hemogenic endothelium and endocardium, suggesting a novel role for
in hemoangiogenic lineage specification and diversification.</description><identifier>ISSN: 2050-084X</identifier><identifier>EISSN: 2050-084X</identifier><identifier>DOI: 10.7554/eLife.20994</identifier><identifier>PMID: 28271994</identifier><language>eng</language><publisher>England: eLife Sciences Publications Ltd</publisher><subject>Animals ; Aorta ; Aorta - embryology ; Biology ; Blood ; cardiogenesis ; CD45 antigen ; Cell lineage ; Chick Embryo ; Coronary vessels ; Developmental Biology and Stem Cells ; Ectopic expression ; Embryos ; Endocardium - embryology ; Endothelium ; Gene expression ; Gene mapping ; Heart ; Heart diseases ; Hemangioblasts - physiology ; hemogenic endothelium ; Homeobox Protein Nkx-2.5 - metabolism ; Laboratories ; Liver ; Mesoderm ; Mice ; Nkx2.5 ; Nkx2.5 protein ; Rodents ; Runx1 protein ; Spatio-Temporal Analysis ; Stem cells ; Transcription factors ; Zebrafish</subject><ispartof>eLife, 2017-03, Vol.6</ispartof><rights>2017, Zamir et al. This work is licensed under the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/3.0/ ) (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2017, Zamir et al 2017 Zamir et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-db683506cfa7604477cbb2035e22567a18b7c9337eb5b73dea254d841e1c8c613</citedby><cites>FETCH-LOGICAL-c517t-db683506cfa7604477cbb2035e22567a18b7c9337eb5b73dea254d841e1c8c613</cites><orcidid>0000-0002-3442-2952 ; 0000-0002-5212-9426 ; 0000-0003-1509-6378 ; 0000-0002-9950-9792</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1952745374/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1952745374?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28271994$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamir, Lyad</creatorcontrib><creatorcontrib>Singh, Reena</creatorcontrib><creatorcontrib>Nathan, Elisha</creatorcontrib><creatorcontrib>Patrick, Ralph</creatorcontrib><creatorcontrib>Yifa, Oren</creatorcontrib><creatorcontrib>Yahalom-Ronen, Yfat</creatorcontrib><creatorcontrib>Arraf, Alaa A</creatorcontrib><creatorcontrib>Schultheiss, Thomas M</creatorcontrib><creatorcontrib>Suo, Shengbao</creatorcontrib><creatorcontrib>Han, Jing-Dong Jackie</creatorcontrib><creatorcontrib>Peng, Guangdun</creatorcontrib><creatorcontrib>Jing, Naihe</creatorcontrib><creatorcontrib>Wang, Yuliang</creatorcontrib><creatorcontrib>Palpant, Nathan</creatorcontrib><creatorcontrib>Tam, Patrick Pl</creatorcontrib><creatorcontrib>Harvey, Richard P</creatorcontrib><creatorcontrib>Tzahor, Eldad</creatorcontrib><title>Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta</title><title>eLife</title><addtitle>Elife</addtitle><description>Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor populations. We show that expression of the cardiac transcription factor
marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. Extra-cardiac
lineage progenitors migrate into the embryo and contribute to clusters of CD41
/CD45
and RUNX1
cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. We also demonstrated that ectopic expression of
in chick embryos activates the hemoangiogenic gene expression program. Taken together, we identified a hemogenic angioblast cell lineage characterized by transient
expression that contributes to hemogenic endothelium and endocardium, suggesting a novel role for
in hemoangiogenic lineage specification and diversification.</description><subject>Animals</subject><subject>Aorta</subject><subject>Aorta - embryology</subject><subject>Biology</subject><subject>Blood</subject><subject>cardiogenesis</subject><subject>CD45 antigen</subject><subject>Cell lineage</subject><subject>Chick Embryo</subject><subject>Coronary vessels</subject><subject>Developmental Biology and Stem Cells</subject><subject>Ectopic expression</subject><subject>Embryos</subject><subject>Endocardium - embryology</subject><subject>Endothelium</subject><subject>Gene expression</subject><subject>Gene mapping</subject><subject>Heart</subject><subject>Heart diseases</subject><subject>Hemangioblasts - physiology</subject><subject>hemogenic endothelium</subject><subject>Homeobox Protein Nkx-2.5 - metabolism</subject><subject>Laboratories</subject><subject>Liver</subject><subject>Mesoderm</subject><subject>Mice</subject><subject>Nkx2.5</subject><subject>Nkx2.5 protein</subject><subject>Rodents</subject><subject>Runx1 protein</subject><subject>Spatio-Temporal Analysis</subject><subject>Stem cells</subject><subject>Transcription factors</subject><subject>Zebrafish</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdks9rFDEUxwdRbKk9eZeAF0F2zc9J5iJI0baw6EXBW3iTvNnNdnZSk0zR_97sbi2tuSR888mX9755TfOa0aVWSn7AVRhwyWnXyWfNKaeKLqiRP58_Op805zlvaV1aGsO6l80JN1yz-uS0wa83v_lSkR2km0xgWofYj5BLJmUDhbg4lRT6uSApkWxwF9c4BUdw8rFscAzzjsShsniQHCS_l2DyxMeUYSQQU4FXzYsBxozn9_tZ8-PL5-8XV4vVt8vri0-rhVNMl4XvWyMUbd0AuqVSau36nlOhkHPVamCm164TQmOvei08AlfSG8mQOeNaJs6a66Ovj7C1tynUtv7YCMEehJjWFlIJbkTbMeg8CKeNA-kVgGNtxymjQvO25lS9Ph69bud-h95hTQLGJ6ZPb6awset4Z5WkVDFeDd7dG6T4a8Zc7C5kh-MIE8Y5W2Z0RTnlsqJv_0O3cU5TjcqyTnEtldB76v2RcinmnHB4KIZRu58Ge5gGe5iGSr95XP8D--_vxV-PebB8</recordid><startdate>20170308</startdate><enddate>20170308</enddate><creator>Zamir, Lyad</creator><creator>Singh, Reena</creator><creator>Nathan, Elisha</creator><creator>Patrick, Ralph</creator><creator>Yifa, Oren</creator><creator>Yahalom-Ronen, Yfat</creator><creator>Arraf, Alaa A</creator><creator>Schultheiss, Thomas M</creator><creator>Suo, Shengbao</creator><creator>Han, Jing-Dong Jackie</creator><creator>Peng, Guangdun</creator><creator>Jing, Naihe</creator><creator>Wang, Yuliang</creator><creator>Palpant, Nathan</creator><creator>Tam, Patrick Pl</creator><creator>Harvey, Richard P</creator><creator>Tzahor, Eldad</creator><general>eLife Sciences Publications Ltd</general><general>eLife Sciences Publications, Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-3442-2952</orcidid><orcidid>https://orcid.org/0000-0002-5212-9426</orcidid><orcidid>https://orcid.org/0000-0003-1509-6378</orcidid><orcidid>https://orcid.org/0000-0002-9950-9792</orcidid></search><sort><creationdate>20170308</creationdate><title>Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta</title><author>Zamir, Lyad ; Singh, Reena ; Nathan, Elisha ; Patrick, Ralph ; Yifa, Oren ; Yahalom-Ronen, Yfat ; Arraf, Alaa A ; Schultheiss, Thomas M ; Suo, Shengbao ; Han, Jing-Dong Jackie ; Peng, Guangdun ; Jing, Naihe ; Wang, Yuliang ; Palpant, Nathan ; Tam, Patrick Pl ; Harvey, Richard P ; Tzahor, Eldad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-db683506cfa7604477cbb2035e22567a18b7c9337eb5b73dea254d841e1c8c613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Aorta</topic><topic>Aorta - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>eLife</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zamir, Lyad</au><au>Singh, Reena</au><au>Nathan, Elisha</au><au>Patrick, Ralph</au><au>Yifa, Oren</au><au>Yahalom-Ronen, Yfat</au><au>Arraf, Alaa A</au><au>Schultheiss, Thomas M</au><au>Suo, Shengbao</au><au>Han, Jing-Dong Jackie</au><au>Peng, Guangdun</au><au>Jing, Naihe</au><au>Wang, Yuliang</au><au>Palpant, Nathan</au><au>Tam, Patrick Pl</au><au>Harvey, Richard P</au><au>Tzahor, Eldad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta</atitle><jtitle>eLife</jtitle><addtitle>Elife</addtitle><date>2017-03-08</date><risdate>2017</risdate><volume>6</volume><issn>2050-084X</issn><eissn>2050-084X</eissn><abstract>Novel regenerative therapies may stem from deeper understanding of the mechanisms governing cardiovascular lineage diversification. Using enhancer mapping and live imaging in avian embryos, and genetic lineage tracing in mice, we investigated the spatio-temporal dynamics of cardiovascular progenitor populations. We show that expression of the cardiac transcription factor
marks a mesodermal population outside of the cardiac crescent in the extraembryonic and lateral plate mesoderm, with characteristics of hemogenic angioblasts. Extra-cardiac
lineage progenitors migrate into the embryo and contribute to clusters of CD41
/CD45
and RUNX1
cells in the endocardium, the aorta-gonad-mesonephros region of the dorsal aorta and liver. We also demonstrated that ectopic expression of
in chick embryos activates the hemoangiogenic gene expression program. Taken together, we identified a hemogenic angioblast cell lineage characterized by transient
expression that contributes to hemogenic endothelium and endocardium, suggesting a novel role for
in hemoangiogenic lineage specification and diversification.</abstract><cop>England</cop><pub>eLife Sciences Publications Ltd</pub><pmid>28271994</pmid><doi>10.7554/eLife.20994</doi><orcidid>https://orcid.org/0000-0002-3442-2952</orcidid><orcidid>https://orcid.org/0000-0002-5212-9426</orcidid><orcidid>https://orcid.org/0000-0003-1509-6378</orcidid><orcidid>https://orcid.org/0000-0002-9950-9792</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | eLife, 2017-03, Vol.6 |
| issn | 2050-084X 2050-084X |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_91a9da3c78ca4d5aac16920103726488 |
| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Animals Aorta Aorta - embryology Biology Blood cardiogenesis CD45 antigen Cell lineage Chick Embryo Coronary vessels Developmental Biology and Stem Cells Ectopic expression Embryos Endocardium - embryology Endothelium Gene expression Gene mapping Heart Heart diseases Hemangioblasts - physiology hemogenic endothelium Homeobox Protein Nkx-2.5 - metabolism Laboratories Liver Mesoderm Mice Nkx2.5 Nkx2.5 protein Rodents Runx1 protein Spatio-Temporal Analysis Stem cells Transcription factors Zebrafish |
| title | Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta |
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