The Impact of PET/CT on Paediatric Oncology

This review paper will discuss the use of positron emission tomography/computed tomography (PET/CT) in paediatric oncology. Functional imaging with PET/CT has proven useful to guide treatment by accurately staging disease and limiting unnecessary treatments by determining the metabolic response to t...

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Bibliographic Details
Published in:Diagnostics (Basel) 2023-01, Vol.13 (2), p.192
Main Authors: Brink, Anita, Hlongwa, Khanyisile N, More, Stuart
Format: Article
Language:English
Subjects:
Biology
Biopsy
Bone marrow
Brain cancer
Chemotherapy
Ewings sarcoma
Langerhans-cell Histiocytosis
Liver
Lymphoma
Medical prognosis
Metastasis
Neuroblastoma
paediatric oncology
Pathology
Patients
Pediatrics
PET/CT
Physiology
Review
sarcoma
Tomography
Tumors
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Summary:This review paper will discuss the use of positron emission tomography/computed tomography (PET/CT) in paediatric oncology. Functional imaging with PET/CT has proven useful to guide treatment by accurately staging disease and limiting unnecessary treatments by determining the metabolic response to treatment. F-Fluorodeoxyglucose (2-[ F]FDG) PET/CT is routinely used in patients with lymphoma. We highlight specific considerations in the paediatric population with lymphoma. The strengths and weaknesses for PET/CT tracers that compliment -[ I]iodobenzylguanidine ([ I]mIBG) for the imaging of neuroblastoma are summarized. 2-[ F]FDG PET/CT has increasingly been used in the staging and evaluation of disease response in sarcomas. The current recommendations for the use of PET/CT in sarcomas are given and potential future developments and highlighted. 2-[ F]FDG PET/CT in combination with conventional imaging is currently the standard for disease evaluation in children with Langerhans-cell Histiocytosis (LCH) and the non-LCH disease spectrum. The common pitfalls of 2-[ F]FDG PET/CT in this setting are discussed.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics13020192