Flavonoids as Modulators of Potassium Channels

Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important...

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Published in:International journal of molecular sciences 2023-01, Vol.24 (2), p.1311
Main Authors: Richter-Laskowska, Monika, Trybek, Paulina, Delfino, Domenico Vittorio, Wawrzkiewicz-Jałowiecka, Agata
Format: Article
Language:English
Subjects:
Antidiabetics
Biological activity
Cancer
Carcinogens
Cell signaling
Channels
Chemical compounds
Diabetes mellitus
Flavonoids
Humans
Hypoglycemic Agents
Inflammation
Investigations
Kinases
Kir channels
Kv channels
Membrane potential
Membranes
Metabolism
Natural products
natural substances
Pharmacology
Physiology
Potassium
potassium channel modulators
Potassium channels
Potassium Channels - physiology
Review
Therapeutic targets
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Summary:Potassium channels are widely distributed integral proteins responsible for the effective and selective transport of K+ ions through the biological membranes. According to the existing structural and mechanistic differences, they are divided into several groups. All of them are considered important molecular drug targets due to their physiological roles, including the regulation of membrane potential or cell signaling. One of the recent trends in molecular pharmacology is the evaluation of the therapeutic potential of natural compounds and their derivatives, which can exhibit high specificity and effectiveness. Among the pharmaceuticals of plant origin, which are potassium channel modulators, flavonoids appear as a powerful group of biologically active substances. It is caused by their well-documented anti-oxidative, anti-inflammatory, anti-mutagenic, anti-carcinogenic, and antidiabetic effects on human health. Here, we focus on presenting the current state of knowledge about the possibilities of modulation of particular types of potassium channels by different flavonoids. Additionally, the biological meaning of the flavonoid-mediated changes in the activity of K+ channels will be outlined. Finally, novel promising directions for further research in this area will be proposed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24021311