Safety and Efficacy of the Metabolic Profiling of the BIMRT Utilizing 18F FDG PET-CT

Aim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal m...

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Published in:Technology in cancer research & treatment 2020, Vol.19, p.1533033820960723-1533033820960723
Main Authors: Dang, Ya-Zheng, Zhang, Dong-Xian, Wang, Guo-Dong, Zhao, Hong-Liang, Huang, Shi-Gao, Li, Jie
Format: Article
Language:English
Subjects:
Chemotherapy
Computed tomography
Metastases
Metastasis
Multivariate analysis
Original
Patients
Peritoneum
Positron emission tomography
Radiation therapy
Survival
Tomography
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Summary:Aim: This study aims to evaluate the safety and efficacy of fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) guided intensity-modulated radiation therapy (IMRT) for patients with peritoneal metastases. Patients and Methods: A total of 55 patients with peritoneal metastases were treated with 18F-FDG-PET/CT-guided IMRT (BIMRT) from January 2012 to January 2019. They were prescribed with a fraction of the median dose of 2 Gy to a total dose of 50.4 Gy. The multivariate analysis was used the Cox proportional hazard model and the Kaplan-Meier plot was used to perform local control rate (LCR), progression-free survival (PFS), and overall survival (OS) analysis. Results: The 1-year, 2-year, and 3-year LCR were 72.7%, 36.4%, and 9.1%, respectively; the 1-year, 2-year, and 3-year PFS were 69.1%, 30.9%, and 7.3%, respectively, and the median PFS time was 18 months. The 1-year, 3-year and 5-year OS were 70.9%, 28.7%, and 4.2%, respectively. Based on the multivariate analysis using the Cox proportional hazard model, the Karnofsky performance status (KPS) score and radiotherapy joint chemotherapy (RJC) method were independent prognostic-related indicators (P < 0.0001). Conclusion: BIMRT may be a safe and effective treatment for patients with peritoneal metastases, especially for patients who cannot undergo surgery. In addition, the results indicated that the patient’s KPS score and RJC method were independent prognostic-related indicators for patients survival time.
ISSN:1533-0346
1533-0338
DOI:10.1177/1533033820960723