Post-sepsis syndrome - an evolving entity that afflicts survivors of sepsis

The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patterns of functional disabilities in sepsis survivors that can last from months to years afte...

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Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2019-12, Vol.26 (1), p.6-14, Article 6
Main Authors: Mostel, Zachary, Perl, Abraham, Marck, Matthew, Mehdi, Syed F, Lowell, Barbara, Bathija, Sagar, Santosh, Ramchandani, Pavlov, Valentin A, Chavan, Sangeeta S, Roth, Jesse
Format: Article
Language:English
Subjects:
Cognition Disorders - etiology
Cognition Disorders - mortality
Cognition Disorders - physiopathology
Cytokines
Disabled Persons - psychology
HMGB1
Humans
Immunology
Infections
Metabolism
Mortality
Pathogens
Pathophysiology
Patients
Post-sepsis syndrome
Quality of life
Quality of Life - psychology
Recovery of Function
Review
Sepsis
Sepsis - complications
Sepsis - mortality
Sepsis - physiopathology
Sepsis sequelae
Sepsis survivors
Survivors - psychology
Well being
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Summary:The sequelae of sepsis were once thought to be independent of sepsis itself and assumed to be either comorbid to sick patients or complications of critical illness. Recent studies have reported consistent patterns of functional disabilities in sepsis survivors that can last from months to years after symptoms of active sepsis had resolved. BODY: Post-sepsis syndrome is an emerging pathological entity that has garnered significant interest amongst clinicians and researchers over the last two decades. It is marked by a significantly increased risk of death and a poor health-related quality of life associated with a constellation of long-term effects that persist following the patient's bout with sepsis. These include neurocognitive impairment, functional disability, psychological deficits, and worsening medical conditions. This "post-sepsis syndrome" has been the subject of active preclinical and clinical research providing new mechanistic insights and approaches linked to survivor well-being. Here we review important aspects of these research efforts and goals of care for patients who survive sepsis.
ISSN:1076-1551
1528-3658
1528-3658
DOI:10.1186/s10020-019-0132-z