Combined treatment in punctate inner choroidopathy

The purpose of this study was to describe a combination treatment for choroidal neovascular (CNV) membrane, secondary to punctate inner choroidopathy (PIC). A 44-year-old female patient was diagnosed with PIC complicated by the development of recurrent juxtafoveal neovascular membrane. The treatment...

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Bibliographic Details
Published in:Therapeutics and clinical risk management 2016-01, Vol.12, p.1467-1471
Main Authors: Terelak-Borys, Barbara, Zagajewska, Katarzyna, Jankowska-Lech, Irmina, Tesla, Piotr, Grabska-Liberek, Iwona
Format: Article
Language:English
Subjects:
Analysis
anti-VEGF injections
Care and treatment
Case Report
Case reports
Dosage and administration
Inflammation
Medical imaging
Membranes
neovascular membrane
Ophthalmology
Patients
Photodynamic therapy
punctate inner choroidopathy
Retinal diseases
steroids
Steroids (Drugs)
Tomography
Treatment outcome
Vascular endothelial growth factor
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Description
Summary:The purpose of this study was to describe a combination treatment for choroidal neovascular (CNV) membrane, secondary to punctate inner choroidopathy (PIC). A 44-year-old female patient was diagnosed with PIC complicated by the development of recurrent juxtafoveal neovascular membrane. The treatment included a sequence of monotherapy regimens: systemic steroid therapy, photodynamic therapy, and intravitreal injections of vascular endothelial growth factor (VEGF) inhibitor (anti-VEGF). Owing to the CNV membrane resistance to various types of monotherapy, a combination treatment consisting of local injections of steroid underneath the Tenon's capsule and intravitreal anti-VEGF injections was used. Systemic steroid therapy resulted in rapid local improvement with a very short remission period. No positive effects of photodynamic therapy were observed. Sequential anti-VEGF injections led to remission periods of several months. Permanent regression of CNV membrane was achieved following combined local application of steroid and intravitreal anti-VEGF injections. A combination treatment including steroid and anti-VEGF medication characterized by anti-inflammatory and antiangiogenic effects may be a very beneficial option for the treatment of recurrent CNV membrane as a complication of PIC.
ISSN:1176-6336
1178-203X
1178-203X
DOI:10.2147/TCRM.S110556