IRON DEPOSITION IN THE GROWTH PLATE OF LONG BONES OF THE OFFSPRING WHEN GIVEN DURING PREGNANCY IN RAT MODEL

Objective: To evaluate histologically the deposition of iron in the epiphyseal cartilage of offspring’s of dams given iron supplementation during pregnancy and lactation in rat model. Study Design: Laboratory based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan Armed Forces medical journal 2021-08, Vol.71 (4), p.1223-26
Main Authors: Umbreen, Faiza, Qamar, Khadija, Shaukat, Sadia, Khan, Maimoona, Malik, Sana, Ali, Hussain
Format: Article
Language:English
Subjects:
Anemia
Anemia in pregnancy
Bones
Cartilage
Diabetes
Digital cameras
epiphyseal cartilage
Females
Ferritin
Hemoglobin
Iron
iron deposition
Laboratories
Oxidative stress
Pregnancy
Rodents
Vagina
Variance analysis
Womens health
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To evaluate histologically the deposition of iron in the epiphyseal cartilage of offspring’s of dams given iron supplementation during pregnancy and lactation in rat model. Study Design: Laboratory based experimental study. Place and Duration of Study: Department of Anatomy, Army Medical College, Rawalpindi and National Institute of Health (NIH) Islamabad, from Mar to Nov 2016. Methodology: In this study, 16 female and 4 male adult rats were chosen for breading. After confirmation of pregnancy, pregnant rats were separated in two groups. One group was given oral iron supplementation for four weeks till delivery and half of the pups fed by mothers who were given iron during lactation. The other group was kept on normal lab diet. Deposition of iron in the epiphyseal cartilage of newborn rats after four weeks was evaluated histologically in pups. Results: Iron deposition was maximum in group C i.e. 1.30 ± 0.48; in group B it was 0.20 ± 0.44. Statistically significant iron deposition (p
ISSN:0030-9648
2411-8842
DOI:10.51253/pafmj.v71i4.4103