The Effects of New Selective PPARα Agonist CP775146 on Systematic Lipid Metabolism in Obese Mice and Its Potential Mechanism

Purpose. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the control of lipid homeostasis. Here, we investigated the effects of CP775146, a new selective PPARα agonist, on lipid metabolism in diet-induced obese mice and its possible mechanism. Methods. C57BL/6 mice were...

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Bibliographic Details
Published in:Journal of diabetes research 2020, Vol.2020 (2020), p.1-9
Main Authors: Zheng, Fenping, Gui, Weiwei, Lin, Xihua, Wu, Fang, Tang, Shengjie, Li, Hong
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - metabolism
Animals
Carbohydrates
Cholesterol
Diet, High-Fat
Drug dosages
Fatty acids
Gene expression
Ligands
Lipid Metabolism - drug effects
Lipids
Liver
Liver - drug effects
Liver - metabolism
Male
Metabolism
Mice
Mice, Obese
Obesity
Obesity - metabolism
Oxidation
PPAR alpha - agonists
Proteins
Statistical analysis
Triglycerides - blood
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Summary:Purpose. Peroxisome proliferator-activated receptor α (PPARα) plays a crucial role in the control of lipid homeostasis. Here, we investigated the effects of CP775146, a new selective PPARα agonist, on lipid metabolism in diet-induced obese mice and its possible mechanism. Methods. C57BL/6 mice were fed a high-fat diet (HFD) for 12 weeks to induce obesity and then received CP775146 via intraperitoneal injection for 3 days. The content/morphology of the liver, serum lipid, and liver function was measured. The expression of genes related to lipolysis and synthesis in liver was detected by quantitative real-time PCR (qRT-PCR). Results. The safe dose of CP775146 was
ISSN:2314-6745
2314-6753
DOI:10.1155/2020/4179852