Effect of intraoperative lung-protective mechanical ventilation on pulmonary oxygenation function and postoperative pulmonary complications after laparoscopic radical gastrectomy

• Published in: Brazilian journal of medical and biological research 2019-01, Vol.52 (6), p.e8523-e8523
• Main Authors: Liu, Jing, Meng, Zhipeng, Lv, Ran, Zhang, Yaping, Wang, Gaojian, Xie, Junran
• Format: Article
• Language: English
• Subjects: BIOLOGY; Cisatracurium; Elderly patients; Gastrectomy; Geriatrics; Health aspects; Infection; Information management; Laparoscopic radical gastrectomy; Laparoscopy; Lung diseases; Lung oxygenation function; Lung-protective ventilation strategy; Lungs; Mechanical ventilation; MEDICINE, RESEARCH & EXPERIMENTAL; Middle age; Middle-aged and elderly people; Oxygenation; Patients; Postoperative pulmonary complication; Remifentanil; Respiratory therapy; Surgery; Ventilation
• ISSN: 0100-879X; 1414-431X; 1414-431X; 1678-4510
• DOI: 10.1590/1414-431x20198523

This study aimed to observe the effects of lung-protective ventilation (LPV) on oxygenation index (OI) and postoperative pulmonary complications (PPCs) after laparoscopic radical gastrectomy in middle-aged and elderly patients. A total of 120 patients who were scheduled to undergo laparoscopic radical gastrectomy with an expected time of >3 h were randomly divided into conventional ventilation (CV group) with tidal volume (TV) of 10 mL/kg without positive end-expiratory pressure (PEEP), and lung-protective ventilation (PV group) with 7 mL/kg TV and personal level of PEEP with regular recruitment maneuver every 30 min. Measurements of OI, modified clinical pulmonary infection score (mCPIS), and PPCs were assessed during the perioperative period. Fifty-seven patients in the CV group and 58 in the PV group participated in the data analysis. Patients in the PV group showed better pulmonary dynamic compliance, OI, and peripheral capillary oxygen saturation during and after surgery. The mCPIS was significantly lower in the PV group than in the CV group after surgery. The incidence rate of PPCs was lower in the PV group than in the CV group and the difference was significant in patients whose ventilation time was longer than 6 h in both groups. LPV during laparoscopic radical gastrectomy significantly improved pulmonary oxygenation function and reduced postoperative mCPIS and the incidence of PPCs during the early period after surgery of middle-aged and elderly patients, especially patients whose mechanical ventilation time was longer than 6 h.