Influence of Surgical Procedures on Serum Paraoxonase-1-Related Variables and Markers of Inflammation in Hospitalized Patients

Purpose: Surgical stress is a phenomenon not completely understood from the biochemical point of view, although it produces alterations in the oxidative balance and inflammatory status. The present study aimed to investigate the alterations of the circulating levels of paraoxonase-1 (PON1)-related v...

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Bibliographic Details
Published in:Journal of investigative surgery 2021-02, Vol.34 (2), p.216-224
Main Authors: Iftimie, Simona, Escribano, Ana, Díez-Sans, Ariadna, Albiciuc, Isabela, Hernández-Aguilera, Anna, Fort-Gallifa, Isabel, López-Azcona, Ana Felisa, Camps, Jordi, Joven, Jorge, Castro, Antoni
Format: Article
Language:English
Subjects:
Aryldialkylphosphatase
Biomarkers
C-reactive protein
C-Reactive Protein - analysis
Case-Control Studies
Humans
Inflammation
Inflammation - diagnosis
Inflammation - etiology
oxidative stress
paraoxonase-1
surgery
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Summary:Purpose: Surgical stress is a phenomenon not completely understood from the biochemical point of view, although it produces alterations in the oxidative balance and inflammatory status. The present study aimed to investigate the alterations of the circulating levels of paraoxonase-1 (PON1)-related variables and markers of inflammation in hospitalized patients who underwent surgery. Methods: We recruited 285 hospitalized patients. Of those, 115 were hospitalized due to a surgical intervention and 170 for reasons other than surgery. The control group consisted of 128 healthy volunteers. A blood sample was obtained for the measurement of serum PON1-related variables, and C-reactive protein (CRP), chemokine (C-C motif) ligand 2 (CCL2), and procalcitonin concentrations. Results: Hospitalized patients had lower serum PON1 activities [paraoxonase: 215.6 (168.6 - 277.8) vs. 298.7 (229.7 - 382.6) U/L, p 
ISSN:0894-1939
1521-0553
DOI:10.1080/08941939.2019.1597223