Neuronal–glial communication perturbations in murine SOD1 G93A spinal cord

In this paper, single-nucleus RNA sequencing was performed to provide a resource of cell-specific niches in the murine ALS model spinal cord at peri-symptomatic onset stage of disease. The data suggest that dysfunctional neuronal-glial communication occurs prior to disease onset, which is partially...

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Bibliographic Details
Published in:Communications biology 2022-02, Vol.5 (1), p.1-16
Main Authors: Michael MacLean, Raquel López-Díez, Carolina Vasquez, Paul F. Gugger, Ann Marie Schmidt
Format: Article
Language:English
Online Access:Get full text
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Summary:In this paper, single-nucleus RNA sequencing was performed to provide a resource of cell-specific niches in the murine ALS model spinal cord at peri-symptomatic onset stage of disease. The data suggest that dysfunctional neuronal-glial communication occurs prior to disease onset, which is partially recapitulated in human post-mortem ALS spinal cord tissue.
ISSN:2399-3642
DOI:10.1038/s42003-022-03128-y