Prospective Evaluation of the BD MAX StaphSR Assay for the Screening of Methicillin-Susceptible and -Resistant Staphylococcus aureus from Nasal Swabs Taken in Intensive Care Unit Patients

Screening patients for S. aureus nasal carriage has proved effective in preventing cross-contamination and endogenous infection with this bacterium. The aim of this study was to assess the performance of the BD MAX StaphSR assay with liquid Amies elution swabs, taken during routine care of intensive...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-09, Vol.24 (18), p.13881
Main Authors: Fayolle, Martin, Epercieux, Amélie, Haddar, Cyrille H., Pillet, Sylvie, Berthelot, Philippe, Pozzetto, Bruno, Carricajo, Anne, Grattard, Florence, Verhoeven, Paul O.
Format: Article
Language:English
Subjects:
BD MAX StaphSR
Intensive care
Ions
methicillin resistance
Methods
MRSA
nasal carrier
nasal swab
Nosocomial infections
Staphylococcus aureus
Staphylococcus infections
Surgical site infections
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Summary:Screening patients for S. aureus nasal carriage has proved effective in preventing cross-contamination and endogenous infection with this bacterium. The aim of this study was to assess the performance of the BD MAX StaphSR assay with liquid Amies elution swabs, taken during routine care of intensive care unit patients. Direct and pre-enriched cultures were used as reference methods to screen for S. aureus and methicillin-resistant S. aureus (MRSA). Discrepant results between the BD MAX StaphSR assay and cultures were resolved by using the Xpert SA Nasal Complete assay. A total of 607 nasal swabs taken from 409 patients were included in this study. Compared to culture methods, the sensitivity and specificity of the BD MAX StaphSR assay were 92.5% and 91.7% for S. aureus screening, and 94.7% and 98.3% for MRSA screening, respectively. In 52 (8.6%) specimens, there was a discrepancy between the results of cultures and the BD MAX StaphSR assay, including 13 (25%) where the results of the BD MAX StaphSR assay were confirmed by the Xpert SA Nasal Complete test. This prospective study showed that the BD MAX StaphSR assay is reliable for S. aureus and MRSA detection from nasal samples taken with liquid Amies elution swabs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241813881