Δ9-Tetrahydrocannabivarin (THCV): a commentary on potential therapeutic benefit for the management of obesity and diabetes

Δ9-Tetrahydrocannabivarin (THCV) is a cannabis-derived compound with unique properties that set it apart from the more common cannabinoids, such as Δ9-tetrahydrocannabinol (THC). The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCV decreases appetite, incr...

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Bibliographic Details
Published in:Journal of cannabis research 2020-01, Vol.2 (1), p.6-6, Article 6
Main Authors: Abioye, Amos, Ayodele, Oladapo, Marinkovic, Aleksandra, Patidar, Risha, Akinwekomi, Adeola, Sanyaolu, Adekunle
Format: Article
Language:English
Subjects:
Alzheimer's disease
Appetite
Brain research
Cannabis sativa (marijuana)
Diabetes
Drug dosages
Food
Glucose
Marijuana
Metabolic syndrome
Nervous system
Obesity
Psychosis
Sucrose
Tetrahydrocannabinol
Tetrahydrocannabinol (THC)
THC
Triglycerides
Δ9-Tetrahydrocannabivarin (THCV)
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Summary:Δ9-Tetrahydrocannabivarin (THCV) is a cannabis-derived compound with unique properties that set it apart from the more common cannabinoids, such as Δ9-tetrahydrocannabinol (THC). The main advantage of THCV over THC is the lack of psychoactive effects. In rodent studies, THCV decreases appetite, increases satiety, and up-regulates energy metabolism, making it a clinically useful remedy for weight loss and management of obesity and type 2 diabetic patients. The distinctions between THCV and THC in terms of glycemic control, glucose metabolism, and energy regulation have been demonstrated in previous studies. Also, the effect of THCV on dyslipidemia and glycemic control in type 2 diabetics showed reduced fasting plasma glucose concentration when compared to a placebo group. In contrast, THC is indicated in individuals with cachexia. However, the uniquely diverse properties of THCV provide neuroprotection, appetite suppression, glycemic control, and reduced side effects, etc.; therefore, making it a potential priority candidate for the development of clinically useful therapies in the future. Hopefully, THCV could provide an optional platform for the treatment of life-threatening diseases.
ISSN:2522-5782
2522-5782
DOI:10.1186/s42238-020-0016-7