Triglyceride-glucose body mass index predicts prognosis in patients with ST-elevation myocardial infarction

• Published in: Scientific reports 2024-01, Vol.14 (1), p.976-976, Article 976
• Main Authors: Liu, Ming, Pan, Jianyuan, Meng, Ke, Wang, Yuwei, Sun, Xueqing, Ma, Likun, Yu, Xiaofan
• Format: Article
• Language: English
• Subjects: 692/163/2743; 692/308/53/2422; Body mass index; Cerebral infarction; Fasting; Heart attacks; Humanities and Social Sciences; Insulin resistance; Medical prognosis; multidisciplinary; Myocardial infarction; Prediction models; Prognosis; Science; Science (multidisciplinary); Statistical analysis; Triglycerides
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-51136-7

Triglyceride glycemic-body mass index (TyG-BMI) is a simple and reliable surrogate for insulin resistance (IR). However, it is still unclear if TyG-BMI has any predictive value in patients having percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI). The purpose of this study was to examine the TyG-BMI index's prognostic significance and predictive power in patients with STEMI. The study comprised a total of 2648 consecutive STEMI patients who underwent PCI. The primary endpoint was the occurrence of major adverse cardiovascular events (MACE), defined as the combination of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and coronary revascularization. The TyG-BMI index was formulated as ln [fasting triglycerides (mg/dL) × fasting plasma glucose (mg/dL)/2] × BMI. 193 patients in all experienced MACE over a median follow-up of 14.7 months. There was a statistically significant difference between the Kaplan–Meier survival curves for the TyG-BMI index tertiles (log-rank test, p  = 0.019) for the cumulative incidence of MACE. The adjusted HRs for the incidence of MACE in the middle and highest quartiles of the TyG-BMI index compared with the lowest quartile were 1.37 (95% CI 0.92, 2.03) and 1.53 (95% CI 1.02, 2.29), respectively, in the fully adjusted Cox regression model. At six months, one year, and three years, the TyG-BMI area under the curve (AUC) for predicting MACE was 0.691, 0.666, and 0.637, respectively. Additionally, adding the TyG-BMI index to the risk prediction model enhanced outcome prediction. In STEMI patients undergoing PCI, TyG-BMI was independently linked to MACE. TyG-BMI could be a simple and solid way to assess MACE risk and prognosis.