Serpin Family A Member 1 Is Prognostic and Involved in Immunological Regulation in Human Cancers

Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human cancers remains unclear. In this study, through comprehensive analysis of data from The Cancer Genome Atlas (TCGA) datasets, we found that S...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-07, Vol.24 (14), p.11566
Main Authors: Kuai, Xingwang, Lv, Jiaying, Zhang, Junyu, Xu, Manyu, Ji, Juling
Format: Article
Language:English
Subjects:
B cells
Biomarkers
Cancer
Comparative analysis
Cytotoxicity
Dendritic cells
Fibroblasts
Genetic aspects
Genetic markers
immune infiltration
Immunology
Immunotherapy
Influence
Lymphocytes
Medical prognosis
Melanoma
Neutrophils
pan-cancer
Prognosis
Protease inhibitors
Proteases
SERPINA1
Tumors
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Summary:Serpin family A member 1 (SERPINA1) encodes a protease inhibitor participating in many human diseases, but its value in immunoregulation and prognosis of human cancers remains unclear. In this study, through comprehensive analysis of data from The Cancer Genome Atlas (TCGA) datasets, we found that SERPINA1 was dysregulated in many cancers compared with normal tissues. SERPINA1 expression was significantly associated with prognosis, immune subtype, molecular subtype, immune checkpoint (ICP) genes, tumor mutational burden (TMB), microsatellite instability (MSI), and the estimation of stromal and immune cells in malignant tumor tissues using expression data (ESTIMATE) score. There was a strong connection between SERPINA1 expression and tumor-infiltrating lymphocytes, and SERPINA1 showed significant relation to gene markers of immune cells in digestive tumors. Fluorescence-based multiplex immunohistochemistry confirmed that SERPINA1 protein expression was related to clinicopathologic features and immune infiltrates in hepatic cancer. This study suggests that SERPINA can potentially serve as a novel biomarker for cancer prognosis and immunotherapy.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms241411566