Oxaliplatin Induced Pulmonary Fibrosis: A Case Report

Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenom...

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Bibliographic Details
Published in:Acta clinica Croatica (Tisak) 2020, Vol.59 (4), p.761-764
Main Author: Pavlović, Mirjana
Format: Article
Language:English
Subjects:
Case Reports
Colon cancer
Interstitial lung disease
Oxaliplatin
Pulmonary fibrosis
Side effects
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Summary:Oxaliplatin is part of the standard chemotherapy regimens for treating colorectal carcinoma. Pulmonary fibrosis is a serious but rare side effect of oxaliplatin treatment, which resulted in patient death in more than half of the reported cases. The precise pathophysiological mechanism of this phenomenon has not been clarified yet. Analysis of the reported cases strongly suggests that early diagnosis and immediate corticosteroid treatment are crucial for better prognosis. Here we report a case of pulmonary fibrosis related to the FOLFOX regimen in a patient with early colorectal carcinoma.
ISSN:0353-9466
1333-9451
DOI:10.20471/acc.2020.59.04.25