Association of the high-sensitive cardiac troponin T levels and long-term mortality in patients with acute aortic dissection type A

• Published in: Journal of cardiovascular and thoracic research 2023-06, Vol.15 (2), p.116-120
• Main Authors: Jenab, Yaser, Ahmadi-Tafti, Seyed-Hossein, Davarpasand, Tahereh, Jalali, Arash, Khederlou, Hamid
• Format: Article
• Language: English
• Subjects: aorta; Aortic dissection; Biomarkers; Blood; cardiac troponin; Coronary vessels; Ischemia; Kinases; Laboratories; Leukocytes; Medical diagnosis; Medical prognosis; Medical treatment; Mortality; Patients; Short Communication; Surgery
• ISSN: 2008-5117; 2008-6830
• DOI: 10.34172/jcvtr.2023.31624

Introduction: Acute aortic dissection type A is a life-threatening cardiovascular emergency necessitating rapid diagnosis and treatment. We sought a new prognostic tool with cardiac biomarkers and simple inflammatory factors. Methods: from 2003 to 2014, 50 patients with documented acute aortic dissection type A were entered to this study. These patients were followed up until December 2020; within median follow up of 93.6 months. The patients were evaluated on the association of the baseline characteristics, first laboratory investigation, echocardiographic findings, surgical approach, and long-term mortality. Results: Total number of mortality during the follow up was 29 (58%) patients, which was significantly higher in medical group (89.4% vs 38.7%, P value=0.001). Multivariable analysis showed only an increase in hs-cTnT levels was suggested as a predictor of mortality (95% CI: 1.06–1.38; HR=1.21; P=0.005), so that for every 100 units increase, patients were 21% more likely to have mortality in long term. Also, performing surgical treatment for aortic dissection was determined as the independent predictor of surviving, so that death was 74.6% less than those who received medical treatment (95% CI: 0.13–0.58; HR=0.27; P=0.001). Conclusion: hs-cTnT is a potential predictor of mortality in patients with acute aortic dissection type A.