Current and prospective therapeutic strategies: tackling Candida albicans and Streptococcus mutans cross-kingdom biofilm

( ) is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of ( ) and in the carious lesions especially in children with early childhood caries (ECC) and demonstrates the close interaction between them. During the interaction...

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Bibliographic Details
Published in:Frontiers in cellular and infection microbiology 2023-05, Vol.13, p.1106231-1106231
Main Authors: Li, Yijun, Huang, Shan, Du, Jingyun, Wu, Minjing, Huang, Xiaojing
Format: Article
Language:English
Subjects:
biofilm
Biofilms
Candida albicans
Cellular and Infection Microbiology
Child
Child, Preschool
cross-kingdom interaction
Dental Caries
Humans
Streptococcus mutans
therapeutic strategies
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Summary:( ) is the most frequent strain associated with cross-kingdom infections in the oral cavity. Clinical evidence shows the co-existence of ( ) and in the carious lesions especially in children with early childhood caries (ECC) and demonstrates the close interaction between them. During the interaction, both and have evolved a complex network of regulatory mechanisms to boost cariogenic virulence and modulate tolerance upon stress changes in the external environment. The intricate relationship and unpredictable consequences pose great therapeutic challenges in clinics, which indicate the demand for emergence of potential antimicrobial therapy with multi-targets or combinatorial therapies. In this article, we present an overview of the clinical significance, and cooperative network of the cross-kingdom interaction between and Furthermore, we also summarize the current strategies for targeting cross-kingdom biofilm.
ISSN:2235-2988
2235-2988
DOI:10.3389/fcimb.2023.1106231