Synthesis and biological evaluation of rigid polycyclic derivatives of the Diels-Alder adduct tricyclo[6.2.1.02,7]undeca-4,9-dien-3,6-dione

Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo[6.2.1....

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2007-02, Vol.12 (2), p.271-282
Main Authors: Ito, Felicia Megumi, Petroni, Jacqueline Marques, de Lima, Dênis Pires, Beatriz, Adilson, Marques, Maria Rita, de Moraes, Manoel Odorico, Costa-Lotufo, Letícia Veras, Montenegro, Raquel Carvalho, Magalhães, Hemerson Iury Ferreira, Pessoa, Cláudia do O
Format: Article
Language:English
Subjects:
7]undecane ring system
Animals
Biological activity
cage-like compounds
Cell Proliferation - drug effects
Chemistry
Diels-Alder adducts
Erythrocytes - drug effects
Hemolysis - drug effects
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Mice
Molecular Conformation
Molecular Structure
Polycyclic Compounds - chemical synthesis
Polycyclic Compounds - chemistry
Polycyclic Compounds - pharmacology
Stereoisomerism
Tricyclo[6.2.1.02
Tumor Cells, Cultured
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Summary:Part of our research program concentrates on the discovery of new bioactive compounds prepared either by total synthesis or molecular transformation of compounds with bioactivity profiles. In this work we have focused our interest on chemical transformations of the Diels-Alder adduct tricyclo[6.2.1.0(2,7)]undeca-4,9-dien-3,6-dione in order to obtain cage-like compounds and derivatives, followed by an evaluation of their biological activity.
ISSN:1420-3049
1420-3049
DOI:10.3390/12020271