Acetylcholinesterase Inhibitor Ameliorates Early Cardiometabolic Disorders in Fructose-Overloaded Rat Offspring

We investigate the role of galantamine on autonomic dysfunction associated with early cardiometabolic dysfunction in the offspring of fructose-overloaded rats. rats received fructose diluted in drinking water (10%) or water for 60 days prior to mating. Fructose overload was maintained until the end...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2024-08, Vol.17 (8), p.1055
Main Authors: de Miranda, Victor Hugo Martins, Dos Santos, Camila Paixão, Neves, Pietra Petrica, Nascimento-Filho, Antonio Viana, Dutra, Marina Rascio Henriques, Bernardes, Nathalia, Irigoyen, Maria Claúdia, De Angelis, Kátia
Format: Article
Language:English
Subjects:
arterial pressure
arterial pressure variability
Blood pressure
Brief Report
Diet
Disease
Drinking water
Drug dosages
Females
Fourier transforms
fructose
galantamine
Glucose
Heart rate
heart rate variability
Hemodynamics
Insulin
Laboratory animals
Metabolic disorders
offspring
Software
Sperm
Time series
Weaning
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Summary:We investigate the role of galantamine on autonomic dysfunction associated with early cardiometabolic dysfunction in the offspring of fructose-overloaded rats. rats received fructose diluted in drinking water (10%) or water for 60 days prior to mating. Fructose overload was maintained until the end of lactation. The offspring (21 days after birth) of control and fructose-overloaded animals were divided into three groups: control (C), fructose (F) and fructose + galantamine (GAL). GAL (5 mg/kg) was administered orally until the offspring were 51 days old. Metabolic, hemodynamic and cardiovascular autonomic modulation were evaluated. The F group showed decreased insulin tolerance (KITT) compared to the C and GAL groups. The F group, in comparison to the C group, had increased arterial blood pressure, heart rate and sympathovagal balance (LF/HF ratio) and a low-frequency band of systolic arterial pressure (LF-SAP). The GAL group, in comparison to the F group, showed increased vagally mediated RMSSD index, a high-frequency band (HF-PI) and decreased LF/HF ratio and variance in SAP (VAR-SAP) and LF-SAP. Correlations were found between HF-PI and KITT (r = 0.60), heart rate (r = -0.65) and MAP (r = -0.71). GAL treatment significantly improved cardiovascular autonomic modulation, which was associated with the amelioration of cardiometabolic dysfunction in offspring of parents exposed to chronic fructose consumption.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph17081055