Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment

Knowledge of the biological effects of molecular hydrogen (H ), hydrogen gas, is constantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, vira...

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Published in:Pharmaceuticals (Basel, Switzerland) Switzerland), 2023-05, Vol.16 (6), p.817
Main Authors: Atiakshin, Dmitri, Kostin, Andrey, Volodkin, Artem, Nazarova, Anna, Shishkina, Viktoriya, Esaulenko, Dmitry, Buchwalow, Igor, Tiemann, Markus, Noda, Mami
Format: Article
Language:English
Subjects:
Antioxidants
Apoptosis
Autophagy
Chemokines
Cytokines
Enzymes
Extracellular matrix
Health aspects
Homeostasis
Hydrogen
Inflammation
local tissue microenvironment
Mast cells
Metabolism
Mitochondria
molecular hydrogen
Oxidative stress
Physiological aspects
Polyamines
reactive oxygen intermediates
Review
secretome
specific mast cell proteases
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Summary:Knowledge of the biological effects of molecular hydrogen (H ), hydrogen gas, is constantly advancing, giving a reason for the optimism in several healthcare practitioners regarding the management of multiple diseases, including socially significant ones (malignant neoplasms, diabetes mellitus, viral hepatitis, mental and behavioral disorders). However, mechanisms underlying the biological effects of H are still being actively debated. In this review, we focus on mast cells as a potential target for H at the specific tissue microenvironment level. H regulates the processing of pro-inflammatory components of the mast cell secretome and their entry into the extracellular matrix; this can significantly affect the capacity of the integrated-buffer metabolism and the structure of the immune landscape of the local tissue microenvironment. The analysis performed highlights several potential mechanisms for developing the biological effects of H and offers great opportunities for translating the obtained findings into clinical practice.
ISSN:1424-8247
1424-8247
DOI:10.3390/ph16060817