Strong Dependence between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma

Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a si...

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Bibliographic Details
Published in:International journal of molecular sciences 2021-02, Vol.22 (4), p.1884
Main Authors: Birková, Anna, Valko-Rokytovská, Marcela, Hubková, Beáta, Zábavníková, Marianna, Mareková, Mária
Format: Article
Language:English
Subjects:
Adult
Aged
autofluorescence
Female
Fluorescence
Humans
Male
malignant melanoma
Melanoma - urine
Middle Aged
Neoplasm Staging
Spectrometry, Fluorescence
Tryptophan - urine
urine
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Summary:Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22041884