Essential Oil from Piper aduncum: Chemical Analysis, Antimicrobial Assessment, and Literature Review

The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance. Terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. The essential oil (EO) of L. (Piperaceae)...

Full description

Saved in:
Bibliographic Details
Published in:Medicines (Basel, Switzerland) Switzerland), 2017-07, Vol.4 (3), p.49
Main Authors: Monzote, Lianet, Scull, Ramón, Cos, Paul, Setzer, William N
Format: Article
Language:English
Subjects:
antimicrobial
chemotypes
cluster analysis
essential oil
parasitic protozoa
Piper aduncum
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The challenge in antimicrobial chemotherapy is to find safe and selective agents with potency that will not be compromised by previously developed resistance. Terrestrial plants could provide new leads to antibacterial, antifungal, or antiprotozoal activity. The essential oil (EO) of L. (Piperaceae) from Cuba was analyzed by gas chromatography-mass spectrometry (GC-MS). A cluster analysis of EO compositions reported in the literature was carried out. The EO was screened against a panel of microorganisms (bacteria, fungi, parasitic protozoa) as well as for cytotoxicity against human cells. In addition, a review of scientific literature and a bibliometric study was also conducted. A total of 90 compounds were identified in the EO, of which camphor (17.1%), viridiflorol (14.5%), and piperitone (23.7%) were the main components. The cluster analysis revealed at least nine different chemotypes. The EO did not show notable activity against bacteria or fungi, but was active against parasitic protozoa. The results from this study indicate from Cuba is a unique chemotype, support the importance of EOs as medicines, and demonstrate the promise of Cuban EO as a chemotherapeutic agent against parasitic protozoal infections.
ISSN:2305-6320
2305-6320
DOI:10.3390/medicines4030049