Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease

Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/refractory Clostridioides difficile infection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not...

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Bibliographic Details
Published in:Therapeutic Advances in Gastroenterology 2020, Vol.13, p.1756284820946904-1756284820946904
Main Authors: Segal, Jonathan P., Mullish, Benjamin H., Quraishi, Mohammed N., Iqbal, Tariq, Marchesi, Julian R., Sokol, Harry
Format: Article
Language:English
Subjects:
Gastroenterology
Life Sciences
Microbiota
Prospects and Challenges into the Role of Gut Microbiome in Health and Disease
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Summary:Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/refractory Clostridioides difficile infection (CDI). The success of FMT for CDI has led to interest in its therapeutic potential in many other disorders. The mechanisms that underpin the efficacy of FMT are not fully understood. Importantly, FMT remains a crucial treatment in managing CDI and understanding the mechanisms that underpin its success will be critical to improve its clinical efficacy, safety and usability. Furthermore, a deeper understanding of this may allow us to expose FMT’s full potential as a therapeutic tool for other disease states. This review will explore the current understanding of the mechanisms underlying the efficacy of FMT across a variety of diseases.
ISSN:1756-2848
1756-283X
1756-2848
DOI:10.1177/1756284820946904