Abrogation of graft ischemia‐reperfusion injury in ischemia‐free liver transplantation

Background Ischemia‐reperfusion injury (IRI) is considered an inherent component of organ transplantation that compromises transplant outcomes and organ availability. The ischemia‐free liver transplantation (IFLT) procedure has been developed to avoid interruption of blood supply to liver grafts. It...

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Published in:Clinical and translational medicine 2022-04, Vol.12 (4), p.e546-n/a
Main Authors: Guo, Zhiyong, Xu, Jinghong, Huang, Shanzhou, Yin, Meixian, Zhao, Qiang, Ju, Weiqiang, Wang, Dongping, Gao, Ningxin, Huang, Changjun, Yang, Lu, Chen, Maogen, Zhang, Zhiheng, Zhu, Zebin, Wang, Linhe, Zhu, Caihui, Zhang, Yixi, Tang, Yunhua, Chen, Haitian, Liu, Kunpeng, Lu, Yuting, Ma, Yi, Hu, Anbin, Chen, Yinghua, Zhu, Xiaofeng, He, Xiaoshun
Format: Article
Language:English
Subjects:
Adenosine
Alanine Transaminase
Antibodies
Apoptosis
Biopsy
Chemokines
Chromatography
Clinical medicine
Cytokines
Discriminant analysis
Enzymes
Gene expression
Humans
Ischemia
Ischemia - pathology
ischemia‐free liver transplantation
ischemia‐reperfusion injury
Kinases
Labeling
Liver
Liver - blood supply
Liver - metabolism
Liver - pathology
Liver Transplantation - methods
Liver transplants
Mass spectrometry
Metabolites
metabolomics
Multivariate analysis
Peptides
Polymerase chain reaction
Proteins
Reperfusion Injury - metabolism
Reperfusion Injury - pathology
Scientific imaging
transcriptomics
Transmission electron microscopy
Transplants & implants
Tumor necrosis factor-TNF
Variance analysis
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Summary:Background Ischemia‐reperfusion injury (IRI) is considered an inherent component of organ transplantation that compromises transplant outcomes and organ availability. The ischemia‐free liver transplantation (IFLT) procedure has been developed to avoid interruption of blood supply to liver grafts. It is unknown how IFLT might change the characteristics of graft IRI. Methods Serum and liver biopsy samples were collected from IFLT and conventional liver transplantation (CLT) recipients. Pathological, metabolomics, transcriptomics, and proteomics analyses were performed to identify the characteristic changes in graft IRI in IFLT. Results Peak aspartate aminotransferase (539.59 ± 661.76 U/L versus 2622.28 ± 3291.57 U/L) and alanine aminotransferase (297.64 ± 549.50 U/L versus 1184.16 ± 1502.76 U/L) levels within the first 7 days and total bilirubin levels by day 7 (3.27 ± 2.82 mg/dl versus 8.33 ± 8.76 mg/dl) were lower in the IFLT versus CLT group (all p values 
ISSN:2001-1326
2001-1326
DOI:10.1002/ctm2.546