Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images

• Published in: Frontiers in physiology 2023-08, Vol.14, p.1251401-1251401
• Main Authors: Huang, Mengde, Maehara, Akiko, Tang, Dalin, Zhu, Jian, Wang, Liang, Lv, Rui, Zhu, Yanwen, Zhang, Xiaoguo, Matsumura, Mitsuaki, Chen, Lijuan, Ma, Genshan, Mintz, Gary S.
• Format: Article
• Language: English
• Subjects: coronary plaque; imagebased plaque models; multilayer artery model; Physiology; plaque stress; vulnerable plaque
• ISSN: 1664-042X; 1664-042X
• DOI: 10.3389/fphys.2023.1251401

Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years. It is well known that arteries have a three-layer structure: intima, media and adventitia. However, in vivo image-based multilayer plaque models are not available in the current literature due to lack of multilayer image segmentation data. A multilayer segmentation and repairing technique was introduced to segment coronary plaque optical coherence tomography (OCT) image to obtain its three-layer vessel structure. A total of 200 OCT slices from 20 patients (13 male; 7 female) were used to construct multilayer and single-layer 3D thin-slice models to calculate plaque stress and strain and compare model differences. Our results indicated that the average maximum plaque stress values of 20 patients from multilayer and single-layer models were 385.13 ± 110.09 kPa and 270.91 ± 95.86 kPa, respectively. The relative difference was 42.2%, with single-layer stress serving as the base value. The average mean plaque stress values from multilayer and single-layer models were 129.59 ± 32.77 kPa and 93.27 ± 18.20 kPa, respectively, with a relative difference of 38.9%. The maximum and mean plaque strain values obtained from the multilayer models were 11.6% and 19.0% higher than those from the single-layer models. Similarly, the maximum and mean cap strains showed increases of 9.6% and 12.9% over those from the single-layer models. These findings suggest that use of multilayer models could improve plaque stress and strain calculation accuracy and may have large impact on plaque progression and vulnerability investigation and potential clinical applications. Further large-scale studies are needed to validate our findings.