Anti‐inflammatory and immune‐mediated therapy for a case of febrile infection‐related epilepsy syndrome with rapid recurrence

Febrile infection‐related epilepsy syndrome (FIRES) is a disease of unknown etiology, characterized by refractory frequent focal seizures, which require prolonged intensive care. We successfully treated a boy with FIRES with anti‐inflammatory and immunosuppressive therapy. This case suggests that an...

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Bibliographic Details
Published in:Clinical case reports 2022-06, Vol.10 (6), p.e5952-n/a
Main Authors: Kurimoto, Tomonori, Matsuoka, Tsuyoshi, Ami, Yuki, Kanno, Koji, Fujii, Takashi, Fujiwara, Naoki, Matsuoka, Takashi
Format: Article
Language:English
Subjects:
Case Report
Case reports
Children & youth
Consent
Convulsions & seizures
Cytokines
Edema
Encephalitis
Epilepsy
Fever
FIRES
granzymes B
high‐dose PHB
Hypothermia
IL‐6
immune therapy
Inflammation
Lymphocytes
Magnetic resonance imaging
Metabolism
methylprednisolone
Monoclonal antibodies
Pathogenesis
PDCD1
Polymorphism
Sodium
tacrolimus
tocilizumab
Urine
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Summary:Febrile infection‐related epilepsy syndrome (FIRES) is a disease of unknown etiology, characterized by refractory frequent focal seizures, which require prolonged intensive care. We successfully treated a boy with FIRES with anti‐inflammatory and immunosuppressive therapy. This case suggests that an autoimmune mechanism may play a role in the development of FIRES. Immune suppression was effective in a patient with short‐term relapse, suggesting the probability of an immune‐mediated mechanism for Febrile infection‐related epilepsy syndrome.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.5952