In search of quality evidence for lifestyle management and glycemic control in children and adolescents with type 2 diabetes: A systematic review

• Published in: BMC pediatrics 2010-12, Vol.10 (1), p.97-97, Article 97
• Main Authors: Johnson, Steven T, Newton, Amanda S, Chopra, Meera, Buckingham, Jeanette, Huang, Terry T K, Franks, Paul W, Jetha, Mary M, Ball, Geoff D C
• Format: Article
• Language: English
• Subjects: Adolescent; Analysis; Behavior; Blood Glucose - metabolism; Child; Children; Children & youth; Clinical medicine; Combined Modality Therapy - methods; Data collection; Design; Development and progression; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - diet therapy; Diabetes Mellitus, Type 2 - therapy; Diagnosis; Diet, Carbohydrate-Restricted; Exercise; Glycated Hemoglobin A - analysis; Glycosylated hemoglobin; Health aspects; Health sciences; Hospitals; Humans; Life Style; Lifestyles; Medical research; Mortality; Nutrition research; Obesity - diet therapy; Obesity - therapy; Pediatrics; Physiological aspects; Public health; Quality of life; Retrospective Studies; Studies; Teenagers; Treatment Outcome; Type 2 diabetes; Youth
• ISSN: 1471-2431; 1471-2431
• DOI: 10.1186/1471-2431-10-97

Our purpose was to evaluate the impact of lifestyle behavior modification on glycemic control among children and youth with clinically defined Type 2 Diabetes (T2D). We conducted a systematic review of studies (randomized trials, quasi-experimental studies) evaluating lifestyle (diet and/or physical activity) modification and glycemic control (HbA1c). Our data sources included bibliographic databases (EMBASE, CINAHL®, Cochrane Library, Medline®, PASCAL, PsycINFO®, and Sociological Abstracts), manual reference search, and contact with study authors. Two reviewers independently selected studies that included any intervention targeting diet and/or physical activity alone or in combination as a means to reduce HbA1c in children and youth under the age of 18 with T2D. Our search strategy generated 4,572 citations. The majority of citations were not relevant to the study objective. One study met inclusion criteria. In this retrospective study, morbidly obese youth with T2D were treated with a very low carbohydrate diet. This single study received a quality index score of < 11, indicating poor study quality and thus limiting confidence in the study's conclusions. There is no high quality evidence to suggest lifestyle modification improves either short- or long-term glycemic control in children and youth with T2D. Additional research is clearly warranted to define optimal lifestyle behaviour strategies for young people with T2D.