A Little Experience Goes a Long Way: Chlormethine/Mechlorethamine Treatment Duration as a Function of Clinician-Level Patient Volume for Mycosis Fungoides Cutaneous T-Cell Lymphoma (MF-CTCL)—A Retrospective Cohort Study

Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions. We evaluated over 4,000 patients and found an association of clinician case volume with treatment duration and early discontinuation of chlorm...

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Bibliographic Details
Published in:Frontiers in medicine 2021-07, Vol.8, p.679294-679294
Main Authors: Querfeld, Christiane, Pacheco, Theresa, Haverkos, Bradley, Binder, Gary, Angello, James, Poligone, Brian
Format: Article
Language:English
Subjects:
chlormethine gel
cutaneous T-cell lymphoma
dermatitis
mechlorethamine
Medicine
patient volume
treatment outcomes
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Summary:Topical chlormethine yields high response rates in mycosis fungoides cutaneous T-cell lymphoma with early discontinuation often attributed to skin reactions. We evaluated over 4,000 patients and found an association of clinician case volume with treatment duration and early discontinuation of chlormethine gel. The minority of clinicians with high patient volume markedly outperformed clinicians with only few patients on both outcome parameters, yet case volume as low as five patients seemed to mark a threshold for avoiding early discontinuation of treatment regimen.
ISSN:2296-858X
2296-858X
DOI:10.3389/fmed.2021.679294