Quantitative investigation of factors relevant to the T cell spot test for tuberculosis infection in active tuberculosis

Previous qualitative studies suggested that the false negative rate of the T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients. However, more precise quantitative studies are lacking. The purpose of this study was to investigate the f...

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Bibliographic Details
Published in:BMC infectious diseases 2019-07, Vol.19 (1), p.673-673, Article 673
Main Authors: Li, Kui, Yang, Caiyong, Jiang, Zicheng, Liu, Shengxi, Liu, Jun, Fan, Chuanqi, Li, Tao, Dong, Xuemin
Format: Article
Language:English
Subjects:
Albumin
BCG
Diagnosis
Financial planners
IGRA
Medical tests
Regression analysis
Risk factors
T cells
T-SPOT.TB
Testing
Tuberculosis
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Summary:Previous qualitative studies suggested that the false negative rate of the T cell spot test for tuberculosis infection (T-SPOT.TB) is associated with many risk factors in tuberculosis patients. However, more precise quantitative studies are lacking. The purpose of this study was to investigate the factors affecting quantified spot-forming cells (SFCs) to early secreted antigenic target 6 kDa (ESAT-6) or culture filtrate protein 10 kDa (CFP-10) in patients with active tuberculosis. We retrospectively analyzed the data of 360 patients who met the inclusion criteria. Using the SFCs to ESAT-6 or CFP-10 levels as dependent variables, variables with statistical significance in the univariate analysis were subjected to optimal scaling regression analysis. The combination of ESAT-6 and CFP-10 (i.e., T-SPOT.TB) was analyzed by the exact logistic regression model. The results showed that the SFCs to ESAT-6 regression model had statistical significance (P 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-019-4310-y