Archaeal Genome Guardians Give Insights into Eukaryotic DNA Replication and Damage Response Proteins

As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features. As archae...

Full description

Saved in:
Bibliographic Details
Published in:Archaea 2014-01, Vol.2014 (2014), p.23-46
Main Authors: Shin, David S., Tainer, John A., Pratt, Ashley J.
Format: Article
Language:English
Subjects:
Archaea
Archaea - genetics
Archaeabacteria
Bacteria
BASIC BIOLOGICAL SCIENCES
Binding sites
Biology
Deoxyribonucleic acid
DNA
DNA repair
DNA Repair Enzymes - genetics
DNA Replication
Enzymes
Eukaryota - genetics
Evolution, Molecular
Genetic aspects
Genetic research
Genetics
Genome, Archaeal
Genomes
Genomic Instability
High temperature
Microbiology
Prokaryotes
Proteins
Review
Structure
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As the third domain of life, archaea, like the eukarya and bacteria, must have robust DNA replication and repair complexes to ensure genome fidelity. Archaea moreover display a breadth of unique habitats and characteristics, and structural biologists increasingly appreciate these features. As archaea include extremophiles that can withstand diverse environmental stresses, they provide fundamental systems for understanding enzymes and pathways critical to genome integrity and stress responses. Such archaeal extremophiles provide critical data on the periodic table for life as well as on the biochemical, geochemical, and physical limitations to adaptive strategies allowing organisms to thrive under environmental stress relevant to determining the boundaries for life as we know it. Specifically, archaeal enzyme structures have informed the architecture and mechanisms of key DNA repair proteins and complexes. With added abilities to temperature-trap flexible complexes and reveal core domains of transient and dynamic complexes, these structures provide insights into mechanisms of maintaining genome integrity despite extreme environmental stress. The DNA damage response protein structures noted in this review therefore inform the basis for genome integrity in the face of environmental stress, with implications for all domains of life as well as for biomanufacturing, astrobiology, and medicine.
ISSN:1472-3646
1472-3654
DOI:10.1155/2014/206735