Current Advancements in Transdermal Biosensing and Targeted Drug Delivery

In this manuscript, recent advancements in the area of minimally-invasive transdermal biosensing and drug delivery are reviewed. The administration of therapeutic entities through the skin is complicated by the stratum corneum layer, which serves as a barrier to entry and retards bioavailability. A...

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Bibliographic Details
Published in:Sensors (Basel, Switzerland) Switzerland), 2019-02, Vol.19 (5), p.1028
Main Authors: Pandey, Prem C, Shukla, Shubhangi, Skoog, Shelby A, Boehm, Ryan D, Narayan, Roger J
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Animals
Biosensing Techniques - methods
drug delivery
Drug Delivery Systems - methods
electroporation
Electroporation - methods
fluorescent biosensors
Humans
Iontophoresis
Iontophoresis - methods
luminescent sensors
microfabrication
microfluidics
microneedle
Needles
Pharmaceutical Preparations - administration & dosage
Review
transdermal biosensing
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Summary:In this manuscript, recent advancements in the area of minimally-invasive transdermal biosensing and drug delivery are reviewed. The administration of therapeutic entities through the skin is complicated by the stratum corneum layer, which serves as a barrier to entry and retards bioavailability. A variety of strategies have been adopted for the enhancement of transdermal permeation for drug delivery and biosensing of various substances. Physical techniques such as iontophoresis, reverse iontophoresis, electroporation, and microneedles offer (a) electrical amplification for transdermal sensing of biomolecules and (b) transport of amphiphilic drug molecules to the targeted site in a minimally invasive manner. Iontophoretic delivery involves the application of low currents to the skin as well as the migration of polarized and neutral molecules across it. Transdermal biosensing via microneedles has emerged as a novel approach to replace hypodermic needles. In addition, microneedles have facilitated minimally invasive detection of analytes in body fluids. This review considers recent innovations in the structure and performance of transdermal systems.
ISSN:1424-8220
1424-8220
DOI:10.3390/s19051028