Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils

In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne（CIL） extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for...

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Bibliographic Details
Published in:Neural regeneration research 2016-02, Vol.11 (2), p.270-277
Main Authors: Yoo, Ki-Yeon, Kim, In, Cho, Jeong-Hwi, Ahn, Ji, Park, Joon, Lee, Jae-Chul, Tae, Hyun-Jin, Kim, Dae, Kim, Jong-Dai, Hong, Seongkweon, Won, Moo-Ho, Jun Kang, I
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Biotechnology
Cerebral ischemia
Complications and side effects
Digital cameras
Dosage and administration
Drug therapy
Ischemia
Laboratory animals
Neurons
Patient outcomes
Physiological aspects
保护作用
抗炎作用
沙土鼠
海马CA1区
缺血/再灌注损伤
缺血性脑损伤
野菊花
锥体神经元
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Summary:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne（CIL） extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region（CA1） from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.177735