Robust imaging approach for precise prediction of postoperative lung function in lung cancer patients prior to curative operation

Background To create a combined variable integrating both ventilation and perfusion as measured by preoperative dual‐energy computed tomography (DECT), compare the results with predicted postoperative (PPO) lung function as estimated using conventional methods, and assess agreement with actual posto...

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Bibliographic Details
Published in:Thoracic cancer 2024-01, Vol.15 (1), p.35-43
Main Authors: Kim, Suho, Kim, Jonghoon, Jeong, Uichan, Oh, You Jin, Park, Sung Goo, Lee, Ho Yun
Format: Article
Language:English
Subjects:
dual energy computed tomography (DECT)
Energy
Forced Expiratory Volume
Humans
Hyperventilation
Hypoventilation
Iodine
Lung - diagnostic imaging
Lung - surgery
Lung cancer
Lung diseases
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - surgery
Methods
Original
Patients
perfusion scintigraphy
Pneumonectomy
predicted postoperative (PPO) lung function
Regions
Respiratory Function Tests
Scintigraphy
segment counting
Spirometry
Thoracic surgery
Tomography
Ventilation
Vital Capacity
Volumetric analysis
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Summary:Background To create a combined variable integrating both ventilation and perfusion as measured by preoperative dual‐energy computed tomography (DECT), compare the results with predicted postoperative (PPO) lung function as estimated using conventional methods, and assess agreement with actual postoperative lung function. Methods A total of 33 patients with lung cancer who underwent curative surgery after DECT and perfusion scan were selected. Ventilation and perfusion values were generated from DECT data. In the “combined variable method,” these two variables and clinical variables were linearly regressed to estimate PPO lung function. Six PPO lung function parameters (segment counting, perfusion scan, volume analysis, ventilation map, perfusion map, and combined variable) were compared with actual postoperative lung function using an intraclass correlation coefficient (ICC). Results The segment counting method produced the highest ICC for forced vital capacity (FVC) at 0.93 (p 
ISSN:1759-7706
1759-7714
DOI:10.1111/1759-7714.15153