Loading…
Expression of chemerin correlates with a poor prognosis in female breast cancer patients
Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to i...
Saved in:
| Published in: | Breast cancer targets and therapy 2018-01, Vol.10, p.169-176 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c619t-6618c2cbc31e6af75d6de9861acae49e069263e6893546274e8bc192b177865d3 |
|---|---|
| cites | |
| container_end_page | 176 |
| container_issue | |
| container_start_page | 169 |
| container_title | Breast cancer targets and therapy |
| container_volume | 10 |
| creator | El-Sagheer, Ghada Gayyed, Mariana Ahmad, Asmaa Abd El-Fattah, Aliaa Mohamed, Manar |
| description | Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.
We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients' clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.
We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (
=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (
=0.01). Chemerin expression was significantly correlated with weight (
=0.256,
=0.04), body mass index (
=0.233,
=0.03), tumor size (
=0.235,
=0.03), lymph node metastasis (
=0.265,
=0.045), distant metastasis (
=0.267,
=0.02), and tumor grading, (
=0.421,
=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (
=0.038,
=-0.437, and
=0.047,
=-0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, ( |
| doi_str_mv | 10.2147/BCTT.S178181 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_932c9aa9bda34255a3a7e4658495d33c</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A574315023</galeid><doaj_id>oai_doaj_org_article_932c9aa9bda34255a3a7e4658495d33c</doaj_id><sourcerecordid>A574315023</sourcerecordid><originalsourceid>FETCH-LOGICAL-c619t-6618c2cbc31e6af75d6de9861acae49e069263e6893546274e8bc192b177865d3</originalsourceid><addsrcrecordid>eNptkk1v1DAQhiMEolXpjTOKhIQ4sEv8EX9ckMqqQKVKHFgkbtbEmWy8SuJgJ9D-e7zsUnYR9sHW-JnXmncmy56TYkkJl2_fr9br5RciFVHkUXZOiNQLwgh_fHQ_yy5j3Ba7JQvO5dPsjBVcKybJefbt-m4MGKPzQ-6b3LbYY3BDbn0I2MGEMf_ppjaHfPQ-5GPwm8FHF_PENNhDh3kVEOKUWxgsJgImh8MUn2VPGugiXh7Oi-zrh-v16tPi9vPHm9XV7cIKoqeFEERZaivLCApoZFmLGrUSBCwg11gITQVDoTQruaCSo6os0bQiUipR1uwiu9nr1h62Zgyuh3BvPDjzO-DDxkCYnO3QaEatBtBVDYzTsgQGErkoFddJiNmk9W6vNc5Vj7VNdQToTkRPXwbXmo3_YQQtJFMkCbw-CAT_fcY4md5Fi10HA_o5mtQzUjCudZnQl_-gWz-HIVllKKU8NUsJ9ZfaJKeNGxqf_rU7UXNVSs5IWVCWqOV_qLRr7J31AzYuxU8SXh0ltAjd1EbfzVMag3gKvtmDNvgYAzYPZpBiV400uwk0hwlM-ItjAx_gP_PGfgE2r9Nx</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2224000868</pqid></control><display><type>article</type><title>Expression of chemerin correlates with a poor prognosis in female breast cancer patients</title><source>Publicly Available Content Database</source><source>Taylor & Francis Open Access Journals</source><source>PubMed Central</source><creator>El-Sagheer, Ghada ; Gayyed, Mariana ; Ahmad, Asmaa ; Abd El-Fattah, Aliaa ; Mohamed, Manar</creator><creatorcontrib>El-Sagheer, Ghada ; Gayyed, Mariana ; Ahmad, Asmaa ; Abd El-Fattah, Aliaa ; Mohamed, Manar</creatorcontrib><description>Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.
We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients' clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.
We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (
=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (
=0.01). Chemerin expression was significantly correlated with weight (
=0.256,
=0.04), body mass index (
=0.233,
=0.03), tumor size (
=0.235,
=0.03), lymph node metastasis (
=0.265,
=0.045), distant metastasis (
=0.267,
=0.02), and tumor grading, (
=0.421,
=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (
=0.038,
=-0.437, and
=0.047,
=-0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (
<0.001, sensitivity 89%, and specificity 69%). The Kaplan-Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (
=0.001).
Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients.</description><identifier>ISSN: 1179-1314</identifier><identifier>EISSN: 1179-1314</identifier><identifier>DOI: 10.2147/BCTT.S178181</identifier><identifier>PMID: 30498371</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>adipocyte development ; Adipocytes ; Analysis ; Angiogenesis ; Body mass index ; Breast cancer ; Cancer metastasis ; Cancer patients ; Cancer research ; chemerin expression ; Development and progression ; Disease ; Esophagus ; Estrogens ; Family medical history ; Gene expression ; Genetic aspects ; Health aspects ; Immunohistochemistry ; Inflammation ; Insulin ; Insulin-like growth factors ; Internal medicine ; Ligands ; Lung cancer ; Medical research ; Medicine ; Melanoma ; Metabolic syndrome ; Obesity ; Original Research ; Phenols (Class of compounds) ; Progesterone ; Prognosis ; Sex hormones ; Tumor necrosis factor-TNF ; Tumors ; Women's health</subject><ispartof>Breast cancer targets and therapy, 2018-01, Vol.10, p.169-176</ispartof><rights>COPYRIGHT 2018 Dove Medical Press Limited</rights><rights>2018. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 El-Sagheer et al. This work is published and licensed by Dove Medical Press Limited 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c619t-6618c2cbc31e6af75d6de9861acae49e069263e6893546274e8bc192b177865d3</citedby><orcidid>0000-0001-8769-5199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2224000868/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2224000868?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25744,27915,27916,37003,37004,44581,53782,53784,74887</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30498371$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Sagheer, Ghada</creatorcontrib><creatorcontrib>Gayyed, Mariana</creatorcontrib><creatorcontrib>Ahmad, Asmaa</creatorcontrib><creatorcontrib>Abd El-Fattah, Aliaa</creatorcontrib><creatorcontrib>Mohamed, Manar</creatorcontrib><title>Expression of chemerin correlates with a poor prognosis in female breast cancer patients</title><title>Breast cancer targets and therapy</title><addtitle>Breast Cancer (Dove Med Press)</addtitle><description>Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.
We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients' clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.
We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (
=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (
=0.01). Chemerin expression was significantly correlated with weight (
=0.256,
=0.04), body mass index (
=0.233,
=0.03), tumor size (
=0.235,
=0.03), lymph node metastasis (
=0.265,
=0.045), distant metastasis (
=0.267,
=0.02), and tumor grading, (
=0.421,
=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (
=0.038,
=-0.437, and
=0.047,
=-0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (
<0.001, sensitivity 89%, and specificity 69%). The Kaplan-Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (
=0.001).
Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients.</description><subject>adipocyte development</subject><subject>Adipocytes</subject><subject>Analysis</subject><subject>Angiogenesis</subject><subject>Body mass index</subject><subject>Breast cancer</subject><subject>Cancer metastasis</subject><subject>Cancer patients</subject><subject>Cancer research</subject><subject>chemerin expression</subject><subject>Development and progression</subject><subject>Disease</subject><subject>Esophagus</subject><subject>Estrogens</subject><subject>Family medical history</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Insulin</subject><subject>Insulin-like growth factors</subject><subject>Internal medicine</subject><subject>Ligands</subject><subject>Lung cancer</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Melanoma</subject><subject>Metabolic syndrome</subject><subject>Obesity</subject><subject>Original Research</subject><subject>Phenols (Class of compounds)</subject><subject>Progesterone</subject><subject>Prognosis</subject><subject>Sex hormones</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><subject>Women's health</subject><issn>1179-1314</issn><issn>1179-1314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptkk1v1DAQhiMEolXpjTOKhIQ4sEv8EX9ckMqqQKVKHFgkbtbEmWy8SuJgJ9D-e7zsUnYR9sHW-JnXmncmy56TYkkJl2_fr9br5RciFVHkUXZOiNQLwgh_fHQ_yy5j3Ba7JQvO5dPsjBVcKybJefbt-m4MGKPzQ-6b3LbYY3BDbn0I2MGEMf_ppjaHfPQ-5GPwm8FHF_PENNhDh3kVEOKUWxgsJgImh8MUn2VPGugiXh7Oi-zrh-v16tPi9vPHm9XV7cIKoqeFEERZaivLCApoZFmLGrUSBCwg11gITQVDoTQruaCSo6os0bQiUipR1uwiu9nr1h62Zgyuh3BvPDjzO-DDxkCYnO3QaEatBtBVDYzTsgQGErkoFddJiNmk9W6vNc5Vj7VNdQToTkRPXwbXmo3_YQQtJFMkCbw-CAT_fcY4md5Fi10HA_o5mtQzUjCudZnQl_-gWz-HIVllKKU8NUsJ9ZfaJKeNGxqf_rU7UXNVSs5IWVCWqOV_qLRr7J31AzYuxU8SXh0ltAjd1EbfzVMag3gKvtmDNvgYAzYPZpBiV400uwk0hwlM-ItjAx_gP_PGfgE2r9Nx</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>El-Sagheer, Ghada</creator><creator>Gayyed, Mariana</creator><creator>Ahmad, Asmaa</creator><creator>Abd El-Fattah, Aliaa</creator><creator>Mohamed, Manar</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-8769-5199</orcidid></search><sort><creationdate>20180101</creationdate><title>Expression of chemerin correlates with a poor prognosis in female breast cancer patients</title><author>El-Sagheer, Ghada ; Gayyed, Mariana ; Ahmad, Asmaa ; Abd El-Fattah, Aliaa ; Mohamed, Manar</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c619t-6618c2cbc31e6af75d6de9861acae49e069263e6893546274e8bc192b177865d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>adipocyte development</topic><topic>Adipocytes</topic><topic>Analysis</topic><topic>Angiogenesis</topic><topic>Body mass index</topic><topic>Breast cancer</topic><topic>Cancer metastasis</topic><topic>Cancer patients</topic><topic>Cancer research</topic><topic>chemerin expression</topic><topic>Development and progression</topic><topic>Disease</topic><topic>Esophagus</topic><topic>Estrogens</topic><topic>Family medical history</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Insulin</topic><topic>Insulin-like growth factors</topic><topic>Internal medicine</topic><topic>Ligands</topic><topic>Lung cancer</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Melanoma</topic><topic>Metabolic syndrome</topic><topic>Obesity</topic><topic>Original Research</topic><topic>Phenols (Class of compounds)</topic><topic>Progesterone</topic><topic>Prognosis</topic><topic>Sex hormones</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><topic>Women's health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Sagheer, Ghada</creatorcontrib><creatorcontrib>Gayyed, Mariana</creatorcontrib><creatorcontrib>Ahmad, Asmaa</creatorcontrib><creatorcontrib>Abd El-Fattah, Aliaa</creatorcontrib><creatorcontrib>Mohamed, Manar</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>Breast cancer targets and therapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Sagheer, Ghada</au><au>Gayyed, Mariana</au><au>Ahmad, Asmaa</au><au>Abd El-Fattah, Aliaa</au><au>Mohamed, Manar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of chemerin correlates with a poor prognosis in female breast cancer patients</atitle><jtitle>Breast cancer targets and therapy</jtitle><addtitle>Breast Cancer (Dove Med Press)</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>10</volume><spage>169</spage><epage>176</epage><pages>169-176</pages><issn>1179-1314</issn><eissn>1179-1314</eissn><abstract>Chemerin was reported to regulate adipogenesis, metabolism, and immunity. But, its relation to cancer remains controversial. In breast cancer, chemerin expression has only been studied in serum, however, its expression in tissue, to our knowledge, has not been studied. The aim of this study was to investigate chemerin expression in breast cancer tissue in comparison to the adjacent normal tissue, and to assess its relationship to disease prognosis.
We examined chemerin expression in tissue with immunohistochemistry and analyzed the association of chemerin expression with the patients' clinical and pathological characteristics to determine its role as a predictor of the disease and its relation to disease prognosis.
We detected a significantly higher expression of chemerin in the malignant vs the non-cancerous tissue specimens in 30/53, (56%) patients, (
=0.001). Moreover, its expression was significantly higher in the metastatic lymph nodes in comparison to the tumor tissues, (
=0.01). Chemerin expression was significantly correlated with weight (
=0.256,
=0.04), body mass index (
=0.233,
=0.03), tumor size (
=0.235,
=0.03), lymph node metastasis (
=0.265,
=0.045), distant metastasis (
=0.267,
=0.02), and tumor grading, (
=0.421,
=0.004), while it was inversely significantly correlated with estrogen receptor and progesterone receptor expression in malignant breast tissues (
=0.038,
=-0.437, and
=0.047,
=-0.316), respectively. The area under the receiver operating characteristic curve for chemerin as a predictor of breast cancer was 0.82, (
<0.001, sensitivity 89%, and specificity 69%). The Kaplan-Meier survival curves revealed that patients with higher chemerin expression had worse overall survival in comparison to those with a lower chemerin expression, (
=0.001).
Our results revealed higher chemerin expression in malignant vs adjacent normal breast tissue and lend support to a presumable role of chemerin tissue expression as an independent predictor of poor prognosis in breast cancer patients.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>30498371</pmid><doi>10.2147/BCTT.S178181</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8769-5199</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1179-1314 |
| ispartof | Breast cancer targets and therapy, 2018-01, Vol.10, p.169-176 |
| issn | 1179-1314 1179-1314 |
| language | eng |
| recordid | cdi_doaj_primary_oai_doaj_org_article_932c9aa9bda34255a3a7e4658495d33c |
| source | Publicly Available Content Database; Taylor & Francis Open Access Journals; PubMed Central |
| subjects | adipocyte development Adipocytes Analysis Angiogenesis Body mass index Breast cancer Cancer metastasis Cancer patients Cancer research chemerin expression Development and progression Disease Esophagus Estrogens Family medical history Gene expression Genetic aspects Health aspects Immunohistochemistry Inflammation Insulin Insulin-like growth factors Internal medicine Ligands Lung cancer Medical research Medicine Melanoma Metabolic syndrome Obesity Original Research Phenols (Class of compounds) Progesterone Prognosis Sex hormones Tumor necrosis factor-TNF Tumors Women's health |
| title | Expression of chemerin correlates with a poor prognosis in female breast cancer patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-15T06%3A27%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20chemerin%20correlates%20with%20a%20poor%20prognosis%20in%20female%20breast%20cancer%20patients&rft.jtitle=Breast%20cancer%20targets%20and%20therapy&rft.au=El-Sagheer,%20Ghada&rft.date=2018-01-01&rft.volume=10&rft.spage=169&rft.epage=176&rft.pages=169-176&rft.issn=1179-1314&rft.eissn=1179-1314&rft_id=info:doi/10.2147/BCTT.S178181&rft_dat=%3Cgale_doaj_%3EA574315023%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c619t-6618c2cbc31e6af75d6de9861acae49e069263e6893546274e8bc192b177865d3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2224000868&rft_id=info:pmid/30498371&rft_galeid=A574315023&rfr_iscdi=true |