Dendritic Cell-Based Immunotherapy: The Importance of Dendritic Cell Migration

Dendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immun...

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Bibliographic Details
Published in:Journal of immunology research 2024-04, Vol.2024, p.7827246-11
Main Authors: Song, Min-Seon, Nam, Ji-Hee, Noh, Kyung-Eun, Lim, Dae-Seog
Format: Article
Language:English
Subjects:
Antigen-presenting cells
Autoimmune diseases
Cancer therapies
Cell migration
Cell Movement
Chemokines
Cytokines
Dendritic Cells
Disease
Humans
Immune system
Immunological tolerance
Immunosuppression
Immunosuppressive agents
Immunotherapy
Inflammation
Lymph Nodes
Lymphocytes
Metastasis
Neoplasms - therapy
Patients
Review
Sensory neurons
Signal transduction
Tumor Microenvironment
Tumor necrosis factor-TNF
Tumors
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Summary:Dendritic cells (DCs) are specialized antigen-presenting cells that are crucial for maintaining self-tolerance, initiating immune responses against pathogens, and patrolling body compartments. Despite promising aspects, DC-based immunotherapy faces challenges that include limited availability, immune escape in tumors, immunosuppression in the tumor microenvironment, and the need for effective combination therapies. A further limitation in DC-based immunotherapy is the low population of migratory DC (around 5%–10%) that migrate to lymph nodes (LNs) through afferent lymphatics depending on the LN draining site. By increasing the population of migratory DCs, DC-based immunotherapy could enhance immunotherapeutic effects on target diseases. This paper reviews the importance of DC migration and current research progress in the context of DC-based immunotherapy.
ISSN:2314-8861
2314-7156
2314-7156
DOI:10.1155/2024/7827246