Maternal type 1collagen N-terminal telopeptide levels in severe hyperemesis gravidarum

• Published in: BMC pregnancy and childbirth 2018-12, Vol.18 (1), p.502-502, Article 502
• Main Authors: Sahin, E, Madendag, Y, Eraslan Sahin, M, Tayyar, A T, Col Madendag, I, Gozukucuk, M, Karakukcu, C, Acmaz, G, Muderris, I I
• Format: Article
• Language: English
• Subjects: Adult; Age; Amino acids; Body Mass Index; Bone density; Breastfeeding & lactation; Collagen; Collagen Type I - urine; Correlation of Data; Disease; Electrolytes; Female; Humans; Hyperemesis gravidarum; Hyperemesis Gravidarum - complications; Hyperemesis Gravidarum - diagnosis; Hyperemesis Gravidarum - prevention & control; Hyperemesis Gravidarum - urine; Malnutrition - diagnosis; Malnutrition - etiology; Malnutrition - prevention & control; Osteoporosis; Peptides - urine; Pregnancy; Pregnancy Trimester, First; Research Design; Research Subjects; Severity of Illness Index; Turkey; Urine; Urine Ntx; Urine type 1 collagen N-terminal telopeptide; Vitamin D; Vitamin D deficiency; Vitamin deficiency; Vomiting; Water-Electrolyte Imbalance - diagnosis; Water-Electrolyte Imbalance - etiology; Water-Electrolyte Imbalance - prevention & control; Weight Loss; Womens health
• ISSN: 1471-2393; 1471-2393
• DOI: 10.1186/s12884-018-2149-7

Nausea and vomiting occur 50-90% during the first trimester of pregnancy. However, patients with hyperemesis gravidarum (HG) may be hospitalized at an incidence rate of 0.8-2% before the 20th week of gestational age. The symptoms generally start during the 5-6th gestational weeks, reaching the highest degree during the 9th week, and decline after the 16-20th weeks of gestation. Clinical findings are proportional to the severity of the disease and severe HG is characterized with dehydration, electrolyte imbalance, and nutritional deficiency as a result of vomiting. The study population consisted of two groups of pregnant volunteers at 5-12 weeks of gestation: a severe HG group and a control group. The HG severity was scored using the Pregnancy-Unique Quantification of Emesis (and nausea) (PUQE).The serum levels of the maternal Ca, parathyroid hormone (PTH), Na, K, blood urea nitrogen(BUN), creatinine, vitamin D(25OHD3), and the maternal urine NTx levels were compared between the groups. In total, 40 volunteers were enrolled in this study: 20 healthy pregnant volunteers and 20 with severe HG. There were no statistically significant differences between the maternal characteristics. The first trimester weight loss of ≥5 kg was significantly higher in the severe HG group (p