Chemical ablation of the left ventricular endocardium reduces ventricular fibrillation inducibility in acute ischemic canine heart

• Published in: Journal of arrhythmia 2024-04, Vol.40 (2), p.325-332
• Main Authors: Nitta, Takashi, Asano, Tetsuo, Yajima, Toshimi, Otsuka, Toshiaki, Ishii, Yosuke
• Format: Article
• Language: English
• Subjects: Ablation; Ablation (Surgery); Cardiac arrhythmia; Care and treatment; Catheters; chemical ablation; Complications and side effects; Coronary vessels; Diagnosis; Dogs; Electrocardiography; Electrodes; Health aspects; Heart attacks; Ischemia; left ventricular endocardium; Lugol's solution; Patient outcomes; Veins & arteries; Ventricular fibrillation
• ISSN: 1880-4276; 1883-2148
• DOI: 10.1002/joa3.12993

Objective Ventricular fibrillation remains as the major cause of death in patients with acute myocardial infarction. Effects of trans‐atrial chemical ablation of the left ventricular (LV) endocardium with Lugol's solution on ventricular fibrillation inducibility and ventricular conduction were examined in canines with acute myocardial ischemia. Materials and Methods Chemical ablation of the LV endocardium with Lugol's solution or normal saline was preformed through a left atrial appendage in 14 canines 30 min after occlusion of the left anterior coronary artery. Results Ventricular fibrillation threshold decreased after the coronary artery occlusion and increased after endocardial chemical ablation. There was a significant difference in the ventricular fibrillation threshold after chemical ablation between with Lugol's solution and with normal saline (25.9 ± 9.2 mA vs. 11.3 ± 2.7 mA, p