White matter integrity as a mediator between socioeconomic status and executive function

• Published in: Frontiers in human neuroscience 2022-11, Vol.16, p.1021857-1021857
• Main Authors: Shaked, Danielle, Katzel, Leslie I, Davatzikos, Christos, Gullapalli, Rao P, Seliger, Stephen L, Erus, Guray, Evans, Michele K, Zonderman, Alan B, Waldstein, Shari R
• Format: Article
• Language: English
• Subjects: Aging; Anisotropy; Brain research; Cardiovascular diseases; Cingulum; Cognitive ability; Contraindications; Dementia; diffusion tensor imaging; Executive function; Health care; Health disparities; Life span; Magnetic resonance imaging; Neighborhoods; neuroanatomical health; Neuroimaging; Neuroscience; Psychological aspects; Risk factors; Sensitivity analysis; Sociodemographics; Socioeconomic factors; socioeconomic status; Substantia alba; white matter integrity
• ISSN: 1662-5161; 1662-5161
• DOI: 10.3389/fnhum.2022.1021857

Lower socioeconomic status (SES) is associated with poorer executive function, but the neural mechanisms of this association remain unclear. As healthy brain communication is essential to our cognitive abilities, white matter integrity may be key to understanding socioeconomic disparities. Participants were 201 African American and White adults (ages 33-72) from the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) SCAN study. Diffusion tensor imaging was used to estimate regional fractional anisotropy as a measure of white matter integrity. Adjusting for age, analyses examined if integrity of the anterior limb of the internal capsule (ALIC), external capsule (EC), superior longitudinal fasciculus (SLF), and cingulum mediated SES-executive function relations. Lower SES was related to poorer cognitive performance and white matter integrity. Lower Trails B performance was related to poorer integrity of the ALIC, EC, and SLF, and lower Stroop performance was associated with poorer integrity of the ALIC and EC. ALIC mediated the SES-Trails B relation, and EC mediated the SES-Trails B and SES-Stroop relations. Sensitivity analyses revealed that (1) adjustment for race rendered the EC mediations non-significant, (2) when using poverty status and continuous education as predictors, results were largely the same, (3) at least some of the study's findings may generalize to processing speed, (4) mediations are not age-dependent in our sample, and (5) more research is needed to understand the role of cardiovascular risk factors in these models. Findings demonstrate that poorer white matter integrity helps explain SES disparities in executive function and highlight the need for further clarification of the biopsychosocial mechanisms of the SES-cognition association.