Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of is crucial for effective treatment. This review hig...

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Bibliographic Details
Published in:Frontiers in microbiology 2024-02, Vol.15, p.1331508-1331508
Main Authors: Nguyen, Thanh Quang, Heo, Bo Eun, Jeon, Seunghyeon, Ash, Anwesha, Lee, Heehyun, Moon, Cheol, Jang, Jichan
Format: Article
Language:English
Subjects:
drug resistance
efflux pump
intrinsic-extrinsic drug resistance
Microbiology
Mycobacterium abscessus
mycobacterium drug efficacy
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Summary:, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of is crucial for effective treatment. This review highlights the mechanisms employed by to sustain antibiotic resistance, encompassing not only conventional drugs but also newly discovered drug candidates. This comprehensive analysis aims to identify novel entities capable of overcoming the notorious resistance exhibited by , providing insights for the development of more effective therapeutic interventions.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2024.1331508